Diabetes/Metabolism Research and Reviews ( IF 4.6 ) Pub Date : 2021-09-06 , DOI: 10.1002/dmrr.3493
The authors of Gortazar et al.1 have detected a coding error in the variable “prematurity”. This variable included deliveries occurring not only before 37 weeks of gestation but also deliveries occurring during 37 weeks’ gestation. However, preterm deliveries are determined as birth before 37 weeks’ gestation according to the World Health Organization as it was specified in Methods. The error has been amended and the results shown in the Table 1, Table 2, Figure 3 are now responsive for those changes.
Normoglycemicaa Excluding those with type 1 diabetes, type 2 diabetes, and GDM. n = 704 148 |
Women with GDM n = 35 729 | Odds ratio (95% CI) | P | |
---|---|---|---|---|
Maternal characteristics | ||||
Age (years) | 31.27 | 33.42 | -- | <0.001 |
Hypertension, n (%) | 3,723 (0.53) | 612 (1.71) | 2.76 (2.53-3.01) | <0.001 |
Dyslipidemia, n (%) | 844 (0.12) | 99 (0.28) | 1.95 (1.58-2.40) | <0.001 |
Smoking, n (%) | 39,055 (5.55) | 2,755 (7.71) | 1.56 (1.50-1.62) | <0.001 |
Adverse obstetric outcomes | ||||
Pre-eclampsia, n (%) | 10,115 (1.44) | 916 (2.56) | 1.78 (1.66-1.91) | <0.001 |
Preterm birth, n (%) | 41,099 (6.00) | 2578 (7.31) | 1.21 (1.16-1.26) | p<0.001 |
Caesarean section, n (%) | 180,690 (25.66) | 10,592 (29.64) | 1.10 (1.07-1.12) | <0.001 |
Neonatal outcomes | ||||
Macrosomia, n (%) | 41,607 (6.05) | 3,081 (8.72) | 1.53 (1.49-1.58) | <0.001 |
LGA, n (%) | 89,517 (13.02) | 6,549 (18.53) | 1.56 (1.51-1.60) | <0.001 |
SGA, n (%) | 62,038 (9.03) | 2,882 (8.15) | 0.91 (0.84-0.92) | <0.001 |
- P value was adjusted for maternal age and smoking habit.
- a Excluding those with type 1 diabetes, type 2 diabetes, and GDM.
- Prematurity was calculated using the total number of newborns with gestational age at birth data (683,975 normoglycemic and 35,266 with GDM).
- Birthweight outcomes were calculated using the total number of newborns with weight data (687,396 normoglycaemic and 35,342 GDM).
- The other outcomes were calculated using the total number of deliveries in each group.
2006-2010 | 2011-2015 | |
---|---|---|
Pre-eclampsia, OR (CI 95%) | 2.06 (1.86-2.28) | 1.56 (1.41-1.71) |
Preterm birth, OR (CI 95%) | 1.29 (1.21-1.37) | 1.14 (1.07-1.20) |
Cesarean section, OR (CI 95%) | 1.10 (1.06-1.14) | 1.09 (1.06-1.13) |
Macrosomia, OR (CI 95%) | 1.56 (1.48-1.65) | 1.47 (1.39-1.55) |
LGA, OR (CI 95%) | 1.56 (1.50-1.63) | 1.51 (1.46-1.57) |
SGA, OR (CI 95%) | 0.88 (0.83-0.93) | 0.88 (0.83-0.93) |
Prematurity rates are now calculated by the total number of delivery reports with available gestational age at birth (>97%). Although the rates and OR of preterm births have been modified, the interpretation of odds ratios and trends over time have remained consistent. Moreover, birth weight outcomes were initially calculated by the total number of deliveries. The authors detected that birth weight data were lacking in a slight number of reports. The authors consider that it would be more accurate to calculate the rates of birth weight outcomes by the number of newborns with birth weight data. Delivery reports without birth weight data accounted for less than 2.5%, therefore the figures have been slightly modified. The interpretation of the odds ratio and trends over time have not been altered
中文翻译:
更正
Gortazar 等人的作者。1已检测到变量“早产”中的编码错误。该变量不仅包括妊娠 37 周前的分娩,还包括妊娠 37 周期间的分娩。然而,根据世界卫生组织在方法中的规定,早产被确定为在妊娠 37 周之前出生。错误已得到修正,表 1、表 2、图 3 中显示的结果现在可以响应这些更改。
正常血糖aa 不包括 1 型糖尿病、2 型糖尿病和 GDM 患者。 n = 704 148 |
患有 GDM 的女性 n = 35 729 | 优势比(95% CI) | 磷 | |
---|---|---|---|---|
母体特征 | ||||
年龄(岁) | 31.27 | 33.42 | —— | <0.001 |
高血压,n (%) | 3,723 (0.53) | 612 (1.71) | 2.76 (2.53-3.01) | <0.001 |
血脂异常,n (%) | 844 (0.12) | 99 (0.28) | 1.95 (1.58-2.40) | <0.001 |
吸烟,n (%) | 39,055 (5.55) | 2,755 (7.71) | 1.56 (1.50-1.62) | <0.001 |
不良产科结果 | ||||
先兆子痫,n (%) | 10,115 (1.44) | 916 (2.56) | 1.78 (1.66-1.91) | <0.001 |
早产,n (%) | 41,099 (6.00) | 2578 (7.31) | 1.21 (1.16-1.26) | p<0.001 |
剖腹产,n (%) | 180,690 (25.66) | 10,592 (29.64) | 1.10 (1.07-1.12) | <0.001 |
新生儿结局 | ||||
巨大儿,n (%) | 41,607 (6.05) | 3,081 (8.72) | 1.53 (1.49-1.58) | <0.001 |
LGA, n (%) | 89,517 (13.02) | 6,549 (18.53) | 1.56 (1.51-1.60) | <0.001 |
SGA, n (%) | 62,038 (9.03) | 2,882 (8.15) | 0.91 (0.84-0.92) | <0.001 |
- P值根据产妇年龄和吸烟习惯进行了调整。
- a 不包括 1 型糖尿病、2 型糖尿病和 GDM 患者。
- 使用出生时具有胎龄数据的新生儿总数(683,975 名正常血糖和 35,266 名 GDM)计算早产。
- 使用具有体重数据的新生儿总数(687,396 正常血糖和 35,342 GDM)计算出生体重结果。
- 使用每组的分娩总数计算其他结果。
2006-2010年 | 2011-2015 | |
---|---|---|
先兆子痫,或 (CI 95%) | 2.06 (1.86-2.28) | 1.56 (1.41-1.71) |
早产,或 (CI 95%) | 1.29 (1.21-1.37) | 1.14 (1.07-1.20) |
剖腹产,或 (CI 95%) | 1.10 (1.06-1.14) | 1.09 (1.06-1.13) |
巨大儿,或 (CI 95%) | 1.56 (1.48-1.65) | 1.47 (1.39-1.55) |
LGA, 或 (CI 95%) | 1.56 (1.50-1.63) | 1.51 (1.46-1.57) |
SGA, 或 (CI 95%) | 0.88 (0.83-0.93) | 0.88 (0.83-0.93) |
现在,早产率是通过具有可用出生胎龄 (>97%) 的分娩报告总数来计算的。尽管早产率和 OR 已被修改,但对优势比和趋势的解释仍然保持一致。此外,出生体重结果最初是按分娩总数计算的。作者发现在少量报告中缺乏出生体重数据。作者认为,通过具有出生体重数据的新生儿数量来计算出生体重结果率会更准确。没有出生体重数据的分娩报告占不到2.5%,因此数字略有修改。随着时间的推移,对优势比和趋势的解释没有改变