Dermal substitutes are indispensable for repairing large full-thickness skin defects. Only a few biomaterials for dermal substitution have been put into clinical practice. Therefore, novel artificial dermal substitutes that can meet clinical requirements are in urgent need. Biodegradable poly(4-hydroxybutyrate) (P4HB), which has been approved by the U.S. FDA, can be considered as a possible alternative biomaterial to construct dermal substitutes. In this work, three-dimensional P4HB fibrous membranes were constructed by an electrospinning technique. These P4HB fibrous membranes showed excellent air-permeability, and better water uptake capacity compared to P4HB strip and polycaprolactone (PCL) fibrous membrane controls. The in vitro hemocompatibility and cytotoxicity of P4HB fibrous membranes were investigated. In vivo Sprague-Dawley (SD) rat model studies revealed that P4HB fibrous membranes can be used as artificial dermis to improve wound healing for full-thickness skin defects.

中文翻译：

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可生物吸收的聚（4-羟基丁酸酯）（P4HB）纤维膜作为潜在的皮肤替代品

真皮替代品对于修复大的全层皮肤缺陷是必不可少的。只有少数用于真皮替代的生物材料已投入临床实践。因此，迫切需要能够满足临床需求的新型人工真皮替代物。已获得美国 FDA 批准的可生物降解聚 (4-羟基丁酸酯) (P4HB) 可被视为构建真皮替代品的可能替代生物材料。在这项工作中，通过静电纺丝技术构建了三维 P4HB 纤维膜。与 P4HB 条和聚己内酯 (PCL) 纤维膜对照相比，这些 P4HB 纤维膜表现出优异的透气性和更好的吸水能力。体外的研究了 P4HB 纤维膜的血液相容性和细胞毒性。体内Sprague-Dawley (SD) 大鼠模型研究表明，P4HB 纤维膜可用作人造真皮，以改善全层皮肤缺损的伤口愈合。