Cancer therapeutic strategies based on metal ions,Chemical Science

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Cancer therapeutic strategies based on metal ions
Chemical Science ( IF 7.6 ) Pub Date : 2021-09-02 , DOI: 10.1039/d1sc03516a
Yang Liu _{1,

2} , Yinghui Wang ₁ , Shuyan Song _{1,

2} , Hongjie Zhang _{1,

2,

3}

Affiliation

As a necessary substance to maintain the body's normal life activities, metal ions are ubiquitous in organisms and play a major role in various complex physiological and biochemical processes, such as material transportation, energy conversion, information transmission, metabolic regulation, etc. Their abnormal distribution/accumulation in cells can interfere with these processes, causing irreversible physical damage to cells or activating biochemical reactions to induce cell death. Therefore, metal ions can be exploited against a wide spectrum of cancers with high efficiency and without drug resistance, which can effectively inhibit the growth of cancer cells by triggering biocatalysis, breaking the osmotic balance, affecting metabolism, interfering with signal transduction, damaging DNA, etc. This perspective systematically summarizes the latest research progress of metal ion-based anti-tumor therapy, and emphasizes the challenges and development directions of this type of therapeutic strategy, hoping to provide a general implication for future research.

中文翻译：

基于金属离子的癌症治疗策略

金属离子作为维持机体正常生命活动的必需物质，在生物体中普遍存在，在物质运输、能量转换、信息传递、代谢调节等各种复杂的生理生化过程中发挥着重要作用。 /在细胞中的积累会干扰这些过程，对细胞造成不可逆的物理损伤或激活生化反应以诱导细胞死亡。因此，金属离子可以高效、无耐药性地针对多种癌症，通过触发生物催化、打破渗透平衡、影响代谢、干扰信号转导、破坏DNA等方式，有效抑制癌细胞的生长。该视角系统总结了金属离子抗肿瘤治疗的最新研究进展，并强调了此类治疗策略面临的挑战和发展方向，希望为未来的研究提供总体启示。

更新日期：2021-09-07

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