Children with cancer require central venous access which carries risk for line-related infections. The necessity of peripheral and central blood cultures is debated for those with fevers. We evaluated and described results for first episode of paired blood cultures from children with cancer who have a central venous line using retrospective database. Blood culture results, laboratory data, and medical outcomes were included. Descriptive analyses of blood culture results and clinical data were performed. There were 190 episodes of paired positive blood cultures with 167 true positive episodes. Of the true positive episodes, 104 (62.3%) were positive in both central and peripheral cultures, 42 (25.1%) were positive in central only cultures, and 21 (12.6%) were positive in peripheral cultures only. Intensive care unit admission within 48 hours after blood cultures (n=33) differed significantly: 28.7% for both central and peripheral, 10% for central only, and 0% for peripheral only (P=0.009). Central line removal (n=34) differed by type of positivity but was not significant: 22.1% for both central and peripheral, 23.8% for central only, and 4.8% for peripheral only (P=0.15). Peripheral blood cultures provided important medical information yet had differences in short-term clinical outcomes. Further evaluation of medical decision making is warranted.

中文翻译：

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配对中心血和外周血培养对癌症儿童的影响。

患有癌症的儿童需要中心静脉通路，这会带来导管相关感染的风险。对于发烧的人来说，外周血和中心血培养的必要性存在争议。我们使用回顾性数据库评估并描述了具有中心静脉管的癌症儿童的首次配对血培养结果。包括血培养结果、实验室数据和医疗结果。对血培养结果和临床数据进行描述性分析。配对血培养呈阳性的事件有 190 次，其中真阳性事件有 167 次。在真阳性事件中，104 例 (62.3%) 在中央和外周培养中均呈阳性，42 例 (25.1%) 在仅中央培养中呈阳性，21 例 (12.6%) 仅在外周培养中呈阳性。血培养后 48 小时内入住重症监护病房 (n=33) 差异显着：中枢和外周均为 28.7%，仅中枢为 10%，仅外周为 0% (P=0.009)。中心线移除 (n=34) 因阳性类型而异，但并不显着：中心线和外周线均为 22.1%，仅中心线为 23.8%，仅外周线为 4.8%（P=0.15）。外周血培养提供了重要的医学信息，但短期临床结果存在差异。有必要进一步评估医疗决策。