We review the latest evidence from animal models, studies in humans using electrophysiology, experimental memory paradigms, and non-invasive brain stimulation (NIBS), in the form of transcranial alternating current stimulation (tACS), suggesting that the altered activity in networks that contribute to the autobiographical memory (ABM) deficits may be modifiable. ABM involves a specific brain network of interacting regions that store and retrieve life experiences. Deficits in ABM are early symptoms in patients with Alzheimer's disease (AD), and serve as relevant predictors of disease progression. The possibility to modify the neural substrates of ABM opens exciting avenues for the development of therapeutic approaches. Beyond a summary of the causal role of brain oscillations in ABM, we propose a new approach of modulating brain oscillations using personalized tACS with the possibility of reducing ABM deficits. We suggest that human experimental studies using cognitive tasks, EEG, and tACS can have future translational clinical implications.

中文翻译：

---

通过经颅交流电刺激改善阿尔茨海默病的自传体记忆。

我们回顾了来自动物模型、使用电生理学、实验记忆范式和非侵入性脑刺激 (NIBS) 的人类研究的最新证据，以经颅交流电刺激 (tACS) 的形式表明，网络中的活动改变有助于自传体记忆（ABM）缺陷可能是可以改变的。ABM 涉及存储和检索生活经历的相互作用区域的特定大脑网络。ABM 缺陷是阿尔茨海默病 (AD) 患者的早期症状，也是疾病进展的相关预测因子。修改 ABM 神经基质的可能性为治疗方法的开发开辟了令人兴奋的途径。除了总结大脑振荡在 ABM 中的因果作用之外，我们还提出了一种使用个性化 tACS 调节大脑振荡的新方法，并有可能减少 ABM 缺陷。我们建议使用认知任务、脑电图和 tACS 进行人体实验研究可以具有未来的转化临床意义。