Cerebellar stimulation reduces seizures in animals and in humans with drug-resistant epilepsy. In a pilot safety and feasibility study, we applied continuous cutaneous vibratory stimulation (limb proprioceptive cerebellar stimulation) to foot limb proprioceptive receptors to activate cerebellar, pontine, and thalamic structures in drug-resistant epilepsy patients for 8-h nocturnally up to 6-months after a 4-week pre-treatment control baseline. Seizure frequency was evaluated during the baseline control period, and at 6, 12, and 24 weeks after the control recordings. Five-subjects completed at least the first 6-week treatment. At 12-weeks, the median reduction in seizure frequency was -27.8% (mean reduction = -22.3%). Two subjects continued for 24 weeks, with a decline of -44.1 and -45.4%. This pilot study provides support for further clinical studies into the safety and efficacy of limb proprioceptive cerebellar stimulation for epilepsy.

中文翻译：

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非侵入性肢体本体感觉小脑刺激治疗癫痫的试点安全性和可行性研究。

小脑刺激可减少患有耐药性癫痫的动物和人类的癫痫发作。在一项试点安全性和可行性研究中，我们对足部肢体本体感觉受体应用连续皮肤振动刺激（肢体本体感觉小脑刺激），以激活耐药性癫痫患者的小脑、脑桥和丘脑结构，持续 8 小时，持续 6 个月。 4 周治疗前对照基线后。在基线控制期间以及控制记录后 6、12 和 24 周评估癫痫发作频率。五名受试者至少完成了第一个 6 周的治疗。第 12 周时，癫痫发作频率中位数降低为 -27.8%（平均降低 = -22.3%）。两名受试者持续24周，下降幅度分别为-44.1%和-45.4%。该初步研究为肢体本体感觉小脑刺激治疗癫痫的安全性和有效性的进一步临床研究提供了支持。