The miniscope system is one of the calcium (Ca2+) imaging tools with small size and lightweight and can realize the deep-brain Ca2+ imaging not confined to the cerebral cortex. Combining Ca2+ imaging and electrophysiology recording has been an efficient method for extracting high temporal-spatial resolution signals in the brain. In this study, a particular electrode probe was developed and assembled on the imaging lens to modify the miniscope system. The electrode probe can be tightly integrated into the lens of the miniscope without increasing the volume, weight, and implantation complexity. In vivo tests verified that the proposed modified system has realized the simultaneous recording of Ca2+ signals and local field potential (LFP) signal in the hippocampus CA1 region of an adult mouse.

中文翻译：

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一种用于同时进行体内电生理学和钙成像的改良微型显微镜系统。

微型显微镜系统是一种体积小、重量轻的钙（Ca2+）成像工具，可实现不局限于大脑皮层的深部脑Ca2+成像。结合 Ca2+ 成像和电生理记录已成为提取大脑中高时空分辨率信号的有效方法。在这项研究中，开发了一种特殊的电极探针并将其组装在成像镜头上以修改微型显微镜系统。电极探针可以紧密集成到微型显微镜的镜头中，而不会增加体积、重量和植入复杂性。体内试验证实，改进后的系统实现了成年小鼠海马CA1区Ca2+信号和局部场电位（LFP）信号的同时记录。