Hyper-adaptability, the ability to adapt to changes in the internal environment caused by neurological disorders, is necessary to recover from various disabilities, such as motor paralysis and sensory impairment. In the recovery from motor paralysis, the pre-existing neural pathway of the ipsilateral descending pathway, which is normally suppressed and preserved in the course of development, is activated to contribute to the motor control of the paretic limb. Conversely, in sensory pathways, it remains unclear whether there are compensatory pathways which are beneficial for the recovery of sensory impairment due to damaged unilateral somatosensory pathways, such as thalamic hemorrhage. Here, we investigated the interaction between the left and right somatosensory pathways in healthy humans using paired median nerve somatosensory evoked potentials (SEPs). Paired median nerve SEPs were recorded at CP3 and CP4 with a reference of Fz in the International 10-20 System. The paired median nerve stimulation with different interstimulus intervals (ISIs; 1, 2, 3, 5, 10, 20, 40, 60, and 100 ms) was performed to test the influence of the first stimulus (to the right median nerve) on the P14, P14/N20, and N20/P25 components induced by the second stimulus (left side). Results showed that the first stimulation had no effect on SEP amplitudes (P14, P14/N20, and N20/P25) evoked by the second stimulation in all ISI conditions, suggesting that there might not be a neural connectivity formed by a small number of synapses in the left-right interaction of the somatosensory pathway. Additionally, the somatosensory pathway may be less diverse in healthy participants.

中文翻译：

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健康人体感通路中的对侧和同侧相互作用。

超适应能力，即适应由神经系统疾病引起的内部环境变化的能力，是从运动麻痹和感觉障碍等各种残疾中恢复所必需的。在运动麻痹的恢复过程中，在发育过程中通常被抑制和保留的同侧下行通路的预先存在的神经通路被激活，以促进对瘫痪肢体的运动控制。相反，在感觉通路中，尚不清楚是否存在有利于单侧体感通路受损（如丘脑出血）引起的感觉障碍恢复的代偿通路。这里，我们使用成对的正中神经体感诱发电位 (SEP) 研究了健康人左右体感通路之间的相互作用。在 CP3 和 CP4 处记录成对正中神经 SEP，参考国际 10-20 系统中的 Fz。进行具有不同刺激间隔（ISI；1、2、3、5、10、20、40、60 和 100 ms）的成对正中神经刺激以测试第一次刺激（对右侧正中神经）的影响由第二个刺激引起的 P14、P14/N20 和 N20/P25 分量（左侧）。结果表明，在所有 ISI 条件下，第一次刺激对第二次刺激诱发的 SEP 振幅（P14、P14/N20 和 N20/P25）没有影响，这表明在体感通路的左右相互作用中可能不存在由少量突触形成的神经连接。此外，健康参与者的体感通路可能不太多样化。