ABSTRACT

Remodeling of mitochondrial dynamics and mitochondrial morphology plays a pivotal role in the maintenance of mitochondrial homeostasis in response to pathogenic attacks or stress stimuli. In addition to their role in metabolism and energy production, mitochondria participate in diverse biological functions, including innate immune responses driven by macrophages in response to infections or inflammatory stimuli. Mitofusin-2 (MFN2), a mitochondria-shaping protein regulating mitochondrial fusion and fission, plays a crucial role in linking mitochondrial function and innate immune responses. In this article, we review the role of MFN2 in the regulation of innate immune responses during viral and bacterial infections. We also summarize the current knowledge on the role of MFN2 in coordinating inflammatory, atherogenic, and fibrotic responses. MFN2-mediated crosstalk between mitochondrial dynamics and innate immune responses may determine the outcomes of pathogenic infections.

摘要

线粒体动力学和线粒体形态的重塑在维持线粒体稳态以应对病原体攻击或应激刺激方面发挥着关键作用。除了在新陈代谢和能量产生中的作用外，线粒体还参与多种生物学功能，包括由巨噬细胞驱动的对感染或炎症刺激的先天免疫反应。Mitofusin-2 (MFN2) 是一种调节线粒体融合和裂变的线粒体塑造蛋白，在连接线粒体功能和先天免疫反应方面发挥着至关重要的作用。在本文中，我们回顾了 MFN2 在病毒和细菌感染期间调节先天免疫反应中的作用。我们还总结了目前关于 MFN2 在协调炎症、动脉粥样硬化和纤维化反应中的作用的知识。