The realization of the ability of metabolites to form self-assembled amyloid-like nanostructures was a surprising phenomenon. This discovery paved the way towards understanding the pathophysiology of the inborn error of metabolism disorders from a new perspective, relating them to amyloid-associated diseases that are characterized by the aggregation of proteins and polypeptides. Hence, a 'generic amyloid hypothesis' can be proposed. This theory implies that the formation of amyloid-like structures is a general phenomenon not limited to proteins and reflects a common etiology for both age-related amyloid-associated diseases and inborn error of metabolism disorders. Here, we present a comprehensive survey of the recent research related to metabolite amyloids including their structure formation through self-association, propagation, interactions, transmission, and their role in metabolic disorders and neurodegenerative diseases and their applications for the fabrication of novel materials which implicate metabolite assemblies as a surprising extension to the amyloid scheme.

中文翻译：

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代谢物组装：淀粉样蛋白假说的惊人扩展。

代谢物能够形成自组装的类淀粉样纳米结构的实现是一个令人惊讶的现象。这一发现为从新的角度理解先天性代谢紊乱的病理生理学铺平了道路，将它们与以蛋白质和多肽聚集为特征的淀粉样蛋白相关疾病联系起来。因此，可以提出“通用淀粉样蛋白假说”。该理论表明，淀粉样蛋白样结构的形成是一种不限于蛋白质的普遍现象，反映了与年龄相关的淀粉样蛋白相关疾病和先天性代谢紊乱疾病的共同病因。在这里，我们对与代谢物淀粉样蛋白相关的最新研究进行了全面调查，包括它们通过自缔合、传播、