当前位置: X-MOL 学术Mol. Catal. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Efficient access to quinolines and quinazolines by ruthenium complexes catalyzed acceptorless dehydrogenative coupling of 2-aminoarylmethanols with ketones and nitriles
Molecular Catalysis ( IF 3.9 ) Pub Date : 2021-09-06 , DOI: 10.1016/j.mcat.2021.111773
Shuaicong Huo 1 , Siqi Kong 1 , Guang Zeng 2 , Qi Feng 1 , Zhiqiang Hao 1 , Zhangang Han 1 , Jin Lin 1 , Guo-Liang Lu 3
Affiliation  

Treatment of N,N,O-tridentate pyrazolyl-pyridinyl-alcohol ligands, 2-(CR1R2OH)-6-[3,5-(R3)2C3HN2]C5H3N (R1 = R2 = Me, R3 = H (L1H); R1 = Me, R2 = Ph, R3 = H (L2H); R1 = R2 = Ph, R3 = H (L3H); R1 = R2 = R3 = Me (L4H)) with RuCl3•xH2O in refluxing EtOH afforded the corresponding Ru(III) complexes L2RuCl (1a-1d), which were well characterized by IR, HR-MS and X-ray single crystal structural determination. These Ru complexes showed similarly high catalytic performance for both dehydrogenative couplings of 2-aminoarylmethanols with ketones and nitriles, giving the quinolines and quinazolines in good to excellent yields. This protocol provides an atom-economical and sustainable route to access various structurally important quinoline and quinazoline derivatives by using phosphine-free ligand based Ru catalysts.



中文翻译:

通过钌配合物催化2-氨基芳基甲醇与酮和腈的无受体脱氢偶联有效获得喹啉和喹唑啉

N,N,O-三齿吡唑基-吡啶基-醇配体的处理,2-(CR 1 R 2 OH)-6-[3,5-(R 3 ) 2 C 3 HN 2 ]C 5 H 3 N (R 1  = R 2  = Me, R 3  = H ( L1H ); R 1  = Me, R 2  = Ph, R 3  = H ( L2H ); R 1  = R 2  = Ph, R 3  = H ( L3H ); R 1  = R 2  = R 3  = 我(L4H)) 与 RuCl 3 •xH 2 O 在回流的 EtOH 中得到相应的 Ru(III) 配合物 L 2 RuCl ( 1a - 1d ),通过 IR、HR-MS 和 X 射线单晶结构测定对其进行了很好的表征。这些 Ru 配合物对 2-氨基芳基甲醇与酮和腈的脱氢偶联均显示出类似的高催化性能,从而使喹啉和喹唑啉的产率从良好到极好。该协议提供了一种原子经济和可持续的途径,通过使用基于无膦配体的 Ru 催化剂来获取各种结构上重要的喹啉和喹唑啉衍生物。

更新日期:2021-09-06
down
wechat
bug