Treatment of N,N,O-tridentate pyrazolyl-pyridinyl-alcohol ligands, 2-(CR¹R²OH)-6-[3,5-(R³)₂C₃HN₂]C₅H₃N (R¹ = R² = Me, R³ = H (L1H); R¹ = Me, R² = Ph, R³ = H (L2H); R¹ = R² = Ph, R³ = H (L3H); R¹ = R² = R³ = Me (L4H)) with RuCl₃•xH₂O in refluxing EtOH afforded the corresponding Ru(III) complexes L₂RuCl (1a-1d), which were well characterized by IR, HR-MS and X-ray single crystal structural determination. These Ru complexes showed similarly high catalytic performance for both dehydrogenative couplings of 2-aminoarylmethanols with ketones and nitriles, giving the quinolines and quinazolines in good to excellent yields. This protocol provides an atom-economical and sustainable route to access various structurally important quinoline and quinazoline derivatives by using phosphine-free ligand based Ru catalysts.

N,N,O-三齿吡唑基-吡啶基-醇配体的处理，2-(CR ¹ R ² OH)-6-[3,5-(R ³ ) ₂ C ₃ HN ₂ ]C ₅ H ₃ N (R ¹  = R ²  = Me, R ³  = H ( L1H ); R ¹  = Me, R ²  = Ph, R ³  = H ( L2H ); R ¹  = R ²  = Ph, R ³  = H ( L3H ); R ¹  = R ²  = R ³  = 我（L4H)) 与 RuCl ₃ •xH ₂ O 在回流的 EtOH 中得到相应的 Ru(III) 配合物 L ₂ RuCl ( 1a - 1d )，通过 IR、HR-MS 和 X 射线单晶结构测定对其进行了很好的表征。这些 Ru 配合物对 2-氨基芳基甲醇与酮和腈的脱氢偶联均显示出类似的高催化性能，从而使喹啉和喹唑啉的产率从良好到极好。该协议提供了一种原子经济和可持续的途径，通过使用基于无膦配体的 Ru 催化剂来获取各种结构上重要的喹啉和喹唑啉衍生物。