Nanoparticles have been demonstrated to be effective in targeted drug delivery to tumor due to the enhanced permeability and retention (EPR) effect. However, the inhomogeneous distribution of the nanoparticles in the tumor and the slow release of the drug make the therapeutic effect unsatisfied. Here, we present reactive oxygen species (ROS)-responsive micelles comprising poly (ethylene glycol)-poly(propylene sulfide) (PEG-PPS) for targeted delivery and in situ release of drug. Upon the irradiation of ultrasound, the loaded sonosensitizer hypocrellin (HC) will generate ROS to trigger the disassembly of the micelles and meanwhile realize sonodynamic therapy (SDT) effect of cancer. The in vivo experiment indicates that the HC loaded PEG-PPS are biocompatible and much more efficacious than an equivalent amount of free HC in inhibiting the growth of cancer.

由于增强的渗透性和保留 (EPR) 效应，纳米颗粒已被证明可有效地将药物靶向递送至肿瘤。然而，纳米颗粒在肿瘤中的不均匀分布和药物的缓慢释放使得治疗效果不理想。在这里，我们提出了包含聚（乙二醇）-聚（丙烯硫化物）（PEG-PPS）的活性氧（ROS）响应胶束，用于药物的靶向递送和原位释放。在超声照射下，加载的声敏剂hypocrellin（HC）会产生ROS，触发胶束的分解，同时实现癌症的声动力学治疗（SDT）效果。在体内 实验表明，载有 HC 的 PEG-PPS 具有生物相容性，并且在抑制癌症生长方面比等量的游离 HC 更有效。