L-cysteine capped silver nanoparticles as chiral recognition sensor for ketoprofen enantiomers,Chirality

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L-cysteine capped silver nanoparticles as chiral recognition sensor for ketoprofen enantiomers
Chirality ( IF 2.8 ) Pub Date : 2021-09-05 , DOI: 10.1002/chir.23354
Asma Obaid _{1,

2} , Arniza Khairani Mohd Jamil ₁ , Siti Munirah Saharin _{1,

3} , Sharifah Mohamad _{1,

3}

Affiliation

A simple, inexpensive but effective approach for visual chiral recognition of ketoprofen enantiomers was developed using L-cysteine capped silver nanoparticles (L-Cys-AgNPs) as a colorimetric sensor. Upon the addition of R-ketoprofen to L-Cys-AgNPs, rapid aggregation occurred, and the solution changed color from yellow to green. However, the presence of S-ketoprofen did not induce any color change. The results were characterized using UV-Vis, FESEM, FT-IR, SERS, and zeta potential measurements. The chiral assay described in this work is easily distinguished with the naked eyes or using a UV-Vis spectrometer. The sensor revealed a good linear response to ketoprofen enantiomers in the concentration range of 8.33–33.3 μM with a detection limit of 4.52 μM and relative standard deviation of 3.73%. The proposed method was utilized for the determination of ketoprofen racemic mixtures in water samples and commercial tablets. The method excels by its simplicity, low cost, and good availability of materials.

中文翻译：

L-半胱氨酸封端银纳米粒子作为酮洛芬对映体的手性识别传感器

使用 L-半胱氨酸封端的银纳米粒子 (L-Cys-AgNPs) 作为比色传感器，开发了一种简单、廉价但有效的视觉手性识别酮洛芬对映体的方法。在向 L-Cys-AgNPs 添加 R-酮洛芬后，发生快速聚集，溶液颜色从黄色变为绿色。然而，S-酮洛芬的存在并没有引起任何颜色变化。使用 UV-Vis、FESEM、FT-IR、SERS 和 zeta 电位测量对结果进行了表征。这项工作中描述的手性测定很容易用肉眼或使用 UV-Vis 光谱仪区分。该传感器在 8.33–33.3 μM 的浓度范围内对酮洛芬对映体具有良好的线性响应，检测限为 4.52 μM，相对标准偏差为 3.73%。所提出的方法用于测定水样和商业片剂中的酮洛芬外消旋混合物。该方法的优点是简单、成本低和材料可用性好。

更新日期：2021-10-12

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