Amyloid-β (Aβ) aggregates are one of biomarkers of Alzheimer's disease (AD). It is well known that Aβ aggregates display neurotoxicty or cytotoxicity to neurons. Thus, degrading Aβ aggregates is crucial for exploring the treatment of AD. Moreover, the excessive production of HOCl in the AD brain is an important feature of the disease. Herein, a novel compound MB-O based on methylene blue (MB) skeleton was designed and synthesized. The probe MB-O can specifically react with HOCl, releasing the fluorophore MB with strong fluorescence intensity increase. More importantly, the released MB is capable of degrading Aβ aggregates under red light irradiation.

中文翻译：

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次氯酸激活 MB-O 释放亚甲蓝用于光降解 Aβ 聚集体

淀粉样蛋白-β (Aβ) 聚集体是阿尔茨海默病 (AD) 的生物标志物之一。众所周知，Aβ 聚集体对神经元具有神经毒性或细胞毒性。因此，降解 Aβ 聚集体对于探索 AD 的治疗至关重要。此外，AD脑中HOCl的过量产生是该疾病的一个重要特征。在此，设计并合成了一种基于亚甲基蓝（MB）骨架的新型化合物MB-O。探针MB-O可以与HOCl特异性反应，释放荧光团MB，荧光强度增加。更重要的是，释放的 MB 能够在红光照射下降解 Aβ 聚集体。