Periodontitis is an inflammatory disease initiated by dental deposits. Microorganisms in the dental biofilm induce cell death in epithelial cells, contributing to the breakdown of epithelial barrier function. Recently, dental calculus has also been implicated in pyroptotic cell death in oral epithelium. We analyzed the cytotoxic effects of dental calculus and freeze-dried periodontopathic bacteria on oral epithelial cells and macrophages.

中文翻译：

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牙石颗粒和冻干放线菌和具核梭杆菌对HSC-2口腔上皮细胞和THP-1巨噬细胞的细胞毒作用

牙周炎是一种由牙齿沉积物引发的炎症性疾病。牙齿生物膜中的微生物会诱导上皮细胞中的细胞死亡，从而导致上皮屏障功能的破坏。最近，牙结石也与口腔上皮细胞焦亡有关。我们分析了牙结石和冻干牙周病菌对口腔上皮细胞和巨噬细胞的细胞毒作用。