Avian uncoupling protein (av-UCP) is a key protein for thermoregulation in poultry. A single nucleotide polymorphism (SNP) in the av-UCP gene has been reported in chickens. The purpose of the current study was to clarify the association between this av-UCP gene mutation and thermoregulation in chickens. Wild and mutant type chicks for the av-UCP gene SNP (g. 1270 of the av-UCP gene exon 3 with C to T substitution and amino acid substitution) were exposed to high ambient temperature. Rectal temperature, radiation temperature on the body surface, and the expression of heat dissipation behavior (wing drooping and panting) during heat exposure were measured. In addition, oxygen consumption rate in the thermoneutral zone in wild and mutant type chicks was measured. Changes in wing temperature during heat exposure in wild-type chicks were lower than those in mutants. The latency of continuous wing drooping during heat exposure in wild-type chicks was shorter than in mutant chicks. It was also found that the SNP in the av-UCP gene caused reduced oxygen consumption. These results suggest that the av-UCP gene mutation affects thermoregulation, especially heat production, in chickens.

中文翻译：

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禽类解偶联蛋白基因的单核苷酸多态性与鸡的体温调节有关

禽类解偶联蛋白 (av-UCP) 是家禽体温调节的关键蛋白。已在鸡中报道了 av-UCP 基因中的单核苷酸多态性 (SNP)。本研究的目的是阐明这种 av-UCP 基因突变与鸡体温调节之间的关联。将 av-UCP 基因 SNP 的野生型和突变型小鸡（具有 C 到 T 替换和氨基酸替换的 av-UCP 基因外显子 3 的 g. 1270）暴露在高温环境中。测量直肠温度、体表辐射温度、受热过程中散热行为（翅膀下垂和喘气）的表现。此外，测量了野生和突变型小鸡热中性区的耗氧率。野生型雏鸡热暴露期间翅膀温度的变化低于突变体。野生型雏鸡在热暴露期间连续翅膀下垂的潜伏期比突变型雏鸡短。还发现 av-UCP 基因中的 S​​NP 导致耗氧量减少。这些结果表明，av-UCP 基因突变会影响鸡的体温调节，尤其是产热。