As a viscous high-performance submucosal injection material (SIM) used in endoscopic submucosal dissection (ESD), sodium alginate-based SIM (SA-SIM) was recently introduced as high-performance SIM equivalent to sodium hyaluronate-based SIM (HA-SIM) in Japan. However, a comprehensive, detailed comparison of SA and HA is yet to be performed. In this study, we precisely measured the viscoelastic properties, submucosal elevation height (SEH), and injection pressure (IP). Furthermore, we compared the outcomes of ESD using an ex vivo ESD model. There was no significant difference in SEHs between HA-SIM and SA-SIM at all post-injection times, and the IP of the SA-SIM injection was significantly higher than that of the HA-SIM injection in all conditions (P < 0.0001). The viscosity at high shear rates of SA-SIM was higher than that of HA-SIM; this result was consistent with SEH/IP measurement results. No significant difference was observed in ESD procedure time and total volume of injected SIM between HA-SIM and SA-SIM (18.1 ± 6.7 and 17.8 ± 6.0 min, P = 0.8987; 13.3 ± 5.3 and 11.6 ± 5.9 ml, P = 0.4658, respectively). Although SA-SIM was slightly more difficult to inject than HA-SIM, there was no significant difference in performance between the materials. Thus, this basic study demonstrated that SA-SIM can be used for endoscopic treatment as well as HA-SIM, and supported previous clinical research data.

作为一种用于内窥镜黏膜下剥离术 (ESD) 的粘性高性能黏膜下注射材料 (SIM)，基于海藻酸钠的 SIM (SA-SIM) 最近被引入作为与基于透明质酸钠的 SIM (HA-SIM) 等效的高性能 SIM ） 在日本。但是，尚未对 SA 和 HA 进行全面、详细的比较。在这项研究中，我们精确测量了粘弹性、粘膜下高度 (SEH) 和注射压力 (IP)。此外，我们使用体外实验比较了 ESD 的结果静电放电模型。在所有注射后时间，HA-SIM 和 SA-SIM 之间的 SEH 没有显着差异，并且在所有条件下 SA-SIM 注射的 IP 均显着高于 HA-SIM 注射的 IP（P < 0.0001） . SA-SIM在高剪切速率下的粘度高于HA-SIM；该结果与 SEH/IP 测量结果一致。HA-SIM 和 SA-SIM 之间的 ESD 程序时间和注入 SIM 的总体积没有显着差异（18.1 ± 6.7 和 17.8 ± 6.0 分钟，P = 0.8987；13.3 ± 5.3 和 11.6 ± 5.9 ml，P = 0.4658，分别）。尽管 SA-SIM 比 HA-SIM 更难注入，但材料之间的性能没有显着差异。因此，这项基础研究表明，SA-SIM 与 HA-SIM 一样可用于内窥镜治疗，