Objectives

There is limited information regarding the association between air pollution exposure and stroke incidence. Therefore, this study aimed to assess the associations between short-term exposure to ambient air pollutants and initial hospital admission for ischemic stroke.

Materials and Methods

From the Korea National Health Insurance Service–National Sample Cohort 2002–2013 database in South Korea, 55,852 first hospital admissions for ischemic stroke were identified. A generalized additive Poisson model was used to explore the association between air pollutants, including particulate matter, sulfur dioxide, nitrogen dioxide, and carbon monoxide and admissions for ischemic stroke.

Results

All air pollutant models showed significant associations with ischemic stroke in the single lag model. In all air pollutant models excluding particulate matter 10 μm, a significant association was found between nitrogen dioxide exposure and initial admission for ischemic stroke after adjusting for other pollutants. An increment of 10 μg/m³ in nitrogen dioxide concentration at lag 0 and 14 days corresponded to a 0.259% (95% confidence interval, 0.231–0.287%) and 0.110% (95% confidence interval, 0.097–0.124) increase in initial admission for ischemic stroke, respectively.

Conclusions

The exposure-response relationship between nitrogen dioxide and initial admissions for ischemic stroke was approximately linear, with a sharper response at higher concentrations. Short-term exposure to nitrogen dioxide was positively associated with initial hospital admission for ischemic stroke.

中文翻译：

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2002 年至 2013 年韩国空气污染物与缺血性卒中首次入院的关系

目标

关于空气污染暴露与中风发病率之间关联的信息有限。因此，本研究旨在评估短期暴露于环境空气污染物与缺血性卒中首次入院之间的关系。

材料和方法

从韩国国民健康保险局-2002-2013 年韩国国家样本队列数据库中，确定了 55,852 例首次住院的缺血性卒中。广义加性泊松模型用于探索空气污染物（包括颗粒物、二氧化硫、二氧化氮和一氧化碳）与缺血性中风入院之间的关联。

结果

在单一滞后模型中，所有空气污染物模型均显示与缺血性卒中显着相关。在除 10 μm 颗粒物外的所有空气污染物模型中，在调整其他污染物后，发现二氧化氮暴露与缺血性卒中初始入院之间存在显着关联。在滞后 0 天和 14 天二氧化氮浓度增加 10 μg/m ³对应于初始增加 0.259%（95% 置信区间，0.231–0.287%）和 0.110%（95% 置信区间，0.097–0.124）分别为缺血性卒中入院。

结论

二氧化氮与缺血性卒中初始入院之间的暴露-反应关系近似线性，在较高浓度下反应更明显。短期暴露于二氧化氮与因缺血性卒中首次入院呈正相关。