Type B thymoma in a patient with HIV infection: A case report with a review of HIV and thymoma coexistence,Thoracic Cancer

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Type B thymoma in a patient with HIV infection: A case report with a review of HIV and thymoma coexistence
Thoracic Cancer ( IF 2.3 ) Pub Date : 2021-09-05 , DOI: 10.1111/1759-7714.14135
Yaxuan Zhou _{1,

2} , Zhongxing Bing ₁ , Yingzhi Qin ₁ , Dongjie Ma ₁ , Hongsheng Liu ₁

Affiliation

HIV infection predisposes people to cancer, including AIDS-defining cancers, such as Kaposi sarcoma, and a broad range of non-AIDS-defining cancers. Here we report a case with rare coexistence of HIV and thymoma, and summarize all the comorbid cases that currently exist. We found that in all the cases reported, thymoma occurred when CD4+ counts were within a normal range, but the immune response in peripheral T-cell repertoire remains unknown. In our case, an overview of the immune system under this complicated situation is given for the first time by showing the lymphocyte subpopulations in the blood and the immune cell distribution of the thymoma. This case expands the scope of non-AIDS-defining cancers, and provides insight into the influence of the immune system under two immunocompromising conditions, HIV infection and thymoma.

中文翻译：

HIV感染患者的B型胸腺瘤：回顾HIV和胸腺瘤共存的病例报告

HIV 感染使人们易患癌症，包括定义为 AIDS 的癌症，如卡波西肉瘤，以及范围广泛的非 AIDS 定义的癌症。在这里，我们报告了一个罕见的 HIV 和胸腺瘤并存的病例，并总结了目前存在的所有共存病例。我们发现，在所有报告的病例中，当 CD4+ 计数在正常范围内时发生胸腺瘤，但外周 T 细胞库中的免疫反应仍然未知。在我们的案例中，通过显示血液中的淋巴细胞亚群和胸腺瘤的免疫细胞分布，首次概述了这种复杂情况下的免疫系统。这个案例扩大了非艾滋病定义癌症的范围，并提供了对免疫系统在两种免疫受损情况下的影响的见解，即 HIV 感染和胸腺瘤。

更新日期：2021-10-04

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