Bacterial infection and severe wound inflammation are two primary harmful problems that bring harm to the human body and may cause death when a large-scale skin defect occurs. Thus, developing an effective and quick wound healing strategy for curing skin damage and trauma is vital. This study has developed a multifunctional PLA/gelatin/ZnO nanofiber aerogel with a three-dimensional structure through electrospinning and freeze-drying technology for wound healing. It has validated that the nanofiber aerogel has an excellent antibacterial property and biocompatibility. Meanwhile, benefiting from its three-dimensional nanofiber structure, the PLA/gelatin/ZnO nanofiber aerogel possesses good water absorption and air permeability. In vivo experiments have determined that the PLA/gel/ZnO nanofiber aerogel scaffolds effectively promote skin infection’s wound healing and enhance angiogenesis that is practical with increasing ZnO concentration.

细菌感染和严重的伤口炎症是给人体带来危害的两个主要有害问题，当发生大面积皮肤缺损时可能会导致死亡。因此，开发一种有效且快速的伤口愈合策略来治愈皮肤损伤和创伤至关重要。本研究通过静电纺丝和冷冻干燥技术开发了一种具有三维结构的多功能PLA/明胶/ZnO纳米纤维气凝胶，用于伤口愈合。验证了纳米纤维气凝胶具有优异的抗菌性能和生物相容性。同时，得益于其三维纳米纤维结构，PLA/明胶/ZnO纳米纤维气凝胶具有良好的吸水性和透气性。