Background

High-flow nasal cannula therapy is used as a noninvasive treatment for people with acute respiratory disease. The aim of this study was to assess the impact of high-flow nasal cannula different flow rates on different characteristics of swallowing in healthy volunteers.

Methods

A prospective cohort study where healthy adult volunteers were subject to high-flow nasal cannula at different flow rates (0, 10, 20, 30, 40, and 50 L/min, in random order). The 30-mL water swallow test, repetitive saliva swallowing test, and 0-100 mm visual analog scale assessed aspiration, swallow frequency and effort, respectively.

Findings

Thirty subjects (mean age 30 years) were enrolled. Nine subjects (30.0%) choked at 10, 40 and 50 L/min during the 30-mL water swallow test (p < 0.05). Swallowing effort was increased during flow rates ≥20 compared to 10 L/min (p < 0.05). Flow rates ≥20 L/min resulted in lower number of swallows during the repetitive saliva swallowing test compared to 0 and 10 L/min (p < 0.05).

Interpretation

High-flow nasal cannula flow rates above 40 L/min associated with choking (increased risk of aspiration), and was associated with decreased swallowing function in healthy volunteers. It may be important to assess swallowing function in patients with various clinical conditions and treated with high-flow nasal cannula, especially those at risk of aspiration pneumonia.

中文翻译：

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不同高流量鼻导管流速对吞咽功能的影响

背景

高流量鼻导管治疗被用作急性呼吸道疾病患者的非侵入性治疗。本研究的目的是评估不同流速的高流量鼻插管对健康志愿者不同吞咽特征的影响。

方法

一项前瞻性队列研究，健康成年志愿者接受不同流速（0、10、20、30、40 和 50 L/min，随机顺序）的高流量鼻导管。30 毫升水吞咽测试、重复唾液吞咽测试和 0-100 毫米视觉模拟量表分别评估吸入、吞咽频率和努力。

发现

招募了 30 名受试者（平均年龄 30 岁）。9 名受试者 (30.0%) 在 30 mL 水吞咽试验期间以 10、40 和 50 L/min 的速度窒息 ( p  < 0.05)。与 10 L/min 相比，流速≥20 时吞咽努力增加（p  < 0.05）。与 0 和 10 L/min (p < 0.05) 相比，流速≥20 L/min 导致重复吞咽试验期间吞咽次数减少。

解释

高于 40 L/min 的高流量鼻导管流速与窒息相关（增加误吸风险），并与健康志愿者的吞咽功能下降相关。评估患有各种临床状况并接受高流量鼻导管治疗的患者的吞咽功能可能很重要，尤其是那些有吸入性肺炎风险的患者。