The ongoing coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is posing a great threat to the global economy and public health security. Together with the acknowledged angiotensin-converting enzyme 2, glucose-regulated protein 78, transferrin receptor, AXL, kidney injury molecule-1, and neuropilin 1 are also identified as potential receptors to mediate SARS-CoV-2 infection. Therefore, how to inhibit or delay the binding of SARS-CoV-2 with the abovementioned receptors is a key step for the prevention and treatment of COVID-19. As the third gasotransmitter, hydrogen sulfide (H₂S) plays an important role in many physiological and pathophysiological processes. Recently, survivors were reported to have significantly higher H₂S levels in COVID-19 patients, and mortality was significantly greater among patients with decreased H₂S levels. Considering that the beneficial role of H₂S against COVID-19 and COVID-19-induced comorbidities and multiorgan damage has been well-examined and reported in some excellent reviews, this review will discuss the recent findings on the potential receptors of SARS-CoV-2 and how H₂S modulates the above receptors, in turn blocking SARS-CoV-2 entry into host cells.

中文翻译：

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通过阻断 SARS-CoV-2 与其潜在细胞表面受体之间的相互作用，硫化氢的抗病毒作用

由严重急性呼吸系统综合症冠状病毒 2 (SARS-CoV-2) 引起的 2019 年冠状病毒病 (COVID-19) 大流行正在对全球经济和公共卫生安全构成巨大威胁。与公认的血管紧张素转化酶 2 一起，葡萄糖调节蛋白 78、转铁蛋白受体、AXL、肾损伤分子 1 和神经纤维蛋白 1 也被确定为介导 SARS-CoV-2 感染的潜在受体。因此，如何抑制或延迟SARS-CoV-2与上述受体的结合是预防和治疗COVID-19的关键步骤。作为第三种气体传递体，硫化氢 (H ₂ S) 在许多生理和病理生理过程中起着重要作用。最近，据报道幸存者的 H ₂COVID-19 患者的 S 水平，以及 H ₂ S 水平降低的患者的死亡率显着更高。考虑到 H ₂ S 对 COVID-19 和 COVID-19 诱发的合并症和多器官损伤的有益作用已在一些优秀评论中得到充分研究和报道，本评论将讨论最近关于 SARS-CoV 潜在受体的发现-2 以及 H ₂ S如何调节上述受体，进而阻止 SARS-CoV-2 进入宿主细胞。