Objective. The relationship between RBC indices and metabolic diseases remains unclear. The association between anemia and obesity is also controversial. The present study aimed to investigate the relationship between RBC indices and metabolic diseases caused by obesity and evaluate the effect of body mass index (BMI) on RBC indices on the Ravansar cohort data. Method. For the purpose of this study, 9826 participants aged 35–65 years (5158 females and 4668 males) were recruited in the analyses. A quadratic prediction fit plot investigated the association between RBC indices with BMI and lipid profile. The odds ratio of obesity-related diseases in each quartile category of RBC indices and anemia was estimated using multivariable logistic regression models. Results. Subjects in the fourth quartiles of RBC count, hematocrit (HCT), hemoglobin (HGB), and red cell distribution width (RDW) had a higher risk for obesity-related diseases compared to the first quartiles. However, individuals with the mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin concentration (MCHC) in fourth quartiles had lower ORs of obesity-related diseases. While BMI reduced the effect of RBC count, HCT, HGB, and RDW on the incidence risk of obesity-related disease, it increased the impact of MCV, MCH, and MCHC. There was a negative association between BMI and RBC indices except for RDW. The BMI effect on RBC indices was different in normal and obese individuals. BMI in mild anemia lowered the risk of metabolic diseases, but it increased the risk of metabolic diseases for moderate anemia. Conclusion. A higher risk of obesity-related diseases was observed in the fourth quartiles of RBC count, HCT, HGB, and RDW compared to the first quartiles. However, the incidence risk was lower for MCV, MCH, and MCHC. BMI plays an anemia-type dependent role in the relationship. Consideration should be given to the type of anemia in the relationship between BMI and anemia.

中文翻译：

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伊朗库尔德人口中受体重指数影响的红细胞指数、贫血和肥胖相关疾病之间的关联：伊朗西部队列研究的结果

客观。红细胞指数与代谢疾病之间的关系仍不清楚。贫血与肥胖之间的关联也存在争议。本研究旨在调查 RBC 指数与肥胖引起的代谢疾病之间的关系，并评估体重指数 (BMI) 对 Ravansar 队列数据的 RBC 指数的影响。方法。出于本研究的目的，分析招募了 9826 名年龄在 35-65 岁之间的参与者（5158 名女性和 4668 名男性）。二次预测拟合图研究了 RBC 指数与 BMI 和血脂谱之间的关联。使用多变量逻辑回归模型估计每个四分位红细胞指数和贫血类别中肥胖相关疾病的优势比。结果. 与前四分位数相比，红细胞计数、红细胞比容 (HCT)、血红蛋白 (HGB) 和红细胞分布宽度 (RDW) 第四四分位数的受试者患肥胖相关疾病的风险更高。然而，平均红细胞体积 (MCV)、平均红细胞血红蛋白 (MCH) 和平均红细胞血红蛋白浓度 (MCHC) 在四分之四的个体的肥胖相关疾病的 OR 较低。虽然 BMI 降低了 RBC 计数、HCT、HGB 和 RDW 对肥胖相关疾病发病风险的影响，但它增加了 MCV、MCH 和 MCHC 的影响。除 RDW 外，BMI 和 RBC 指数之间存在负相关。BMI 对红细胞指数的影响在正常和肥胖个体中是不同的。轻度贫血的 BMI 降低了代谢疾病的风险，但增加了中度贫血的代谢疾病的风险。结论。与第一个四分位数相比，在红细胞计数、HCT、HGB 和 RDW 的第四个四分位数中观察到肥胖相关疾病的风险更高。然而，MCV、MCH 和 MCHC 的发病风险较低。BMI 在这种关系中起贫血类型依赖性作用。BMI与贫血的关系应考虑贫血的类型。