Objective. Provide a reference to elucidate the mechanism of circRNAs regulating osteoarthritis (OA) and the clinical treatment. Methods. Herein, articles about circRNAs (hsa-circ) and osteoarthritis in the recent 5 years have been reviewed and the differential expression and regulatory effect of circRNAs in OA deduced. Based on these conclusions and Protein-Protein Interaction (PPI), Gene Ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses of the acquired circRNAs, the potential functions and interactions of circRNAs in OA and the involved signaling pathways are discussed. Results. A total of 33 studies meeting the inclusion criteria were included in this study, and 27 circRNAs were upregulated and 8 circRNAs were downregulated in OA. A total of 31 circRNAs were finally included in the PPI, GO, and KEGG analyses. From PPI, 12 map nodes and 7 map edges were interrelated. VWF had the biggest node and edge size. From GO, VWF showed a majority of the functions. From KEGG, circRNAs are enriched in PI3K/AKT, human papillomavirus infection (HPI), and focal adhesion (FA) pathways, and VWF was involved in major pathways. Conclusion. We found that most articles about circRNAs regulating OA in the recent 5 years focused on the mechanism, especially the absorption effect of circ-miRNA as sponges in the recent 2 years, while most of the articles about their functions addressed ECM and PI3K, AKT, and mTOR signaling pathways. Future studies might focus on the functions of circRNAs, and circRNA VWF, with preferable functions, interactions, and involvement, can be used as a biological indicator to detect OA in clinical practice.

中文翻译：

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circRNA在骨关节炎中的作用研究

客观。为阐明circRNA调控骨关节炎（OA）的机制及临床治疗提供参考。方法。本文回顾了近5年有关circRNAs（hsa-circ）和骨关节炎的文章，并推断了circRNAs在OA中的差异表达和调控作用。基于这些结论和蛋白质-蛋白质相互作用 (PPI)、基因本体论 (GO) 和京都基因和基因组百科全书 (KEGG) 对获得的 circRNA 的分析，circRNA 在 OA 中的潜在功能和相互作用以及所涉及的信号通路是讨论过。结果. 本研究共纳入符合纳入标准的33项研究，OA中27个circRNA上调，8个circRNA下调。最终共有 31 个 circRNA 被纳入 PPI、GO 和 KEGG 分析。从 PPI 来看，12 个地图节点和 7 个地图边是相互关联的。VWF 具有最大的节点和边尺寸。从 GO 开始，VWF 展示了大部分功能。在 KEGG 中，circRNA 富含 PI3K/AKT、人乳头瘤病毒感染 (HPI) 和粘着斑 (FA) 通路，而 VWF 参与主要通路。结论. 我们发现，近 5 年关于 circRNAs 调控 OA 的文章大多集中在机制上，尤其是近 2 年 circ-miRNA 作为海绵的吸收作用，而关于其功能的文章大多针对 ECM 和 PI3K、AKT、和 mTOR 信号通路。未来的研究可能集中在circRNAs的功能上，circRNA VWF具有较好的功能、相互作用和参与度，可作为临床上检测OA的生物学指标。