Development of the visual white matter pathways mediates development of electrophysiological responses in visual cortex,Human Brain Mapping

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Development of the visual white matter pathways mediates development of electrophysiological responses in visual cortex
Human Brain Mapping ( IF 3.5 ) Pub Date : 2021-09-06 , DOI: 10.1002/hbm.25654
Sendy Caffarra _{1,

2,

3,

4} , Sung Jun Joo ₅ , David Bloom _{6,

7} , John Kruper _{6,

7} , Ariel Rokem _{6,

7} , Jason D Yeatman _{1,

2}

Affiliation

The latency of neural responses in the visual cortex changes systematically across the lifespan. Here, we test the hypothesis that development of visual white matter pathways mediates maturational changes in the latency of visual signals. Thirty-eight children participated in a cross-sectional study including diffusion magnetic resonance imaging (MRI) and magnetoencephalography (MEG) sessions. During the MEG acquisition, participants performed a lexical decision and a fixation task on words presented at varying levels of contrast and noise. For all stimuli and tasks, early evoked fields were observed around 100 ms after stimulus onset (M100), with slower and lower amplitude responses for low as compared to high contrast stimuli. The optic radiations and optic tracts were identified in each individual's brain based on diffusion MRI tractography. The diffusion properties of the optic radiations predicted M100 responses, especially for high contrast stimuli. Higher optic radiation fractional anisotropy (FA) values were associated with faster and larger M100 responses. Over this developmental window, the M100 responses to high contrast stimuli became faster with age and the optic radiation FA mediated this effect. These findings suggest that the maturation of the optic radiations over childhood accounts for individual variations observed in the developmental trajectory of visual cortex responses.

中文翻译：

视觉白质通路的发展介导视觉皮层电生理反应的发展

视觉皮层神经反应的潜伏期在整个生命周期中都会发生系统性的变化。在这里，我们测试了视觉白质通路的发育介导视觉信号潜伏期的成熟变化的假设。38 名儿童参加了一项横断面研究，包括扩散磁共振成像 (MRI) 和脑磁图 (MEG) 课程。在 MEG 采集过程中，参与者对以不同对比度和噪声级别呈现的单词执行词汇决策和固定任务。对于所有刺激和任务，在刺激开始 (M100) 后 100 毫秒左右观察到早期诱发场，与高对比度刺激相比，低对比度刺激的响应更慢且幅度更低。基于扩散 MRI 纤维束成像技术，识别出每个人大脑中的视辐射和视束。视辐射的扩散特性预测了 M100 反应，特别是对于高对比度刺激。较高的视辐射各向异性分数 (FA) 值与更快和更大的 M100 响应相关。在这个发育窗口中，M100 对高对比度刺激的反应随着年龄的增长而变得更快，并且视辐射 FA 介导了这种效应。这些发现表明，童年期视辐射的成熟解释了视觉皮层反应发育轨迹中观察到的个体差异。

更新日期：2021-11-01

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