ABR wave I amplitude represents the synapse of auditory nerve fibers with the inner hair cell and is highly correlated with synapse counts. Cochlear synaptopathy, the loss of synaptic connections between inner hair cells and auditory nerve fibers, has been well-demonstrated in animal models of noise-induced hearing loss. The peak-to-peak wave I amplitude was determined at baseline and 2 weeks after noise exposure. We determined the ABR wave I amplitude at 80 dB SPL at the frequencies of 8, 12, 16, 24, and 32 kHz. A total of 69 strains (1–8 mice/strain) were analyzed. A statistically significant post-noise reduction in wave I amplitude was observed in all the tested frequencies (p < 0.00001). We identify distinct patterns of noise susceptibility and make this complete phenotypic dataset available for general use. This data establishes a new resource for the study of NIHL in mice and we hope this database will be a useful tool to expand the research in this field.

ABR 波 I 振幅代表听觉神经纤维与内毛细胞的突触，与突触计数高度相关。耳蜗突触病，即内毛细胞和听觉神经纤维之间的突触连接丧失，已在噪声性听力损失的动物模型中得到充分证明。在基线和噪声暴露后 2 周测定 I 波峰峰值幅度。我们在 8、12、16、24 和 32 kHz 的频率下确定了 80 dB SPL 的 ABR 波 I 幅度。共分析了 69 株（1-8 只小鼠/株）。在所有测试频率（p < 0.00001)。我们确定了不同的噪声敏感性模式，并使这个完整的表型数据集可用于一般用途。该数据为小鼠 NIHL 研究建立了新的资源，我们希望该数据库将成为扩展该领域研究的有用工具。