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Alterations in fast-twitch muscle membrane conductance regulation do not explain decreased muscle function of SOD1G93A rats
Muscle & Nerve ( IF 2.8 ) Pub Date : 2021-09-05 , DOI: 10.1002/mus.27413
Pieter A Leermakers 1 , Martin Skov 1 , Anders Riisager 1 , Ole B Nielsen 1 , Thomas H Pedersen 1
Affiliation  

Both neuromuscular junction (NMJ) dysfunction and altered electrophysiological properties of muscle fibers have been reported in amyotrophic lateral sclerosis (ALS) patients. ALS-related preclinical studies typically use rodent SOD1G93A overexpression models, but translation to the human disease has been challenged. The present work explored NMJ function and cellular electrophysiological properties of muscles fibers in SOD1G93A overexpression rats.

中文翻译:

快缩肌膜电导调节的改变不能解释 SOD1G93A 大鼠的肌肉功能下降

在肌萎缩侧索硬化症 (ALS) 患者中报告了神经肌肉接头 (NMJ) 功能障碍和肌纤维电生理特性的改变。ALS 相关的临床前研究通常使用啮齿动物 SOD1 G93A过表达模型,但对人类疾病的转化受到了挑战。目前的工作探讨了 SOD1 G93A过表达大鼠肌肉纤维的 NMJ 功能和细胞电生理特性。
更新日期:2021-09-05
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