Chronobiological models postulate that abnormalities in circadian rest/activity rhythms (CRAR) are core phenomena of bipolar disorders (BDs). We undertook a meta-analysis of published studies to determine whether self- or observer ratings of CRAR differentiate BD cases from comparators (typically healthy controls [HCs]).

中文翻译：

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双相情感障碍的时间型和昼夜休息活动节律：自我和观察者评分量表的荟萃分析

时间生物学模型假设昼夜休息/活动节律 (CRAR) 异常是双相情感障碍 (BDs) 的核心现象。我们对已发表的研究进行了荟萃分析，以确定 CRAR 的自我或观察者评分是否将 BD 病例与比较者（通常是健康对照 [HCs]）区分开来。