There has been an increasing interest in researching on the effects of extremely low-frequency magnetic fields on living systems. The mechanism of action of extremely low-frequency magnetic fields on organisms has not been established. One of the hypotheses is related to induce changes in oxidative balance. In this study, we measured the effects of chronic unpredictable mild stress induced-oxidative balance of rat’s brain exposed to extremely low-frequency magnetic fields. A first experiment was conducted to find out if 14 days of chronic unpredictable mild stress caused oxidative unbalance in male Wistar rat’s brain. Catalase activity, reduced glutathione concentration, and lipoperoxidation were measured in cerebrum and cerebellum. In the second experiment, we investigate the effects of 7 days extremely low-frequency magnetic fields exposure on animals stressed and unstressed. The main results obtained were a significant increase in the catalase activity and reduced glutathione concentration on the cerebrum of animals where the chronic unpredictable mild stress were suspended at day 14 and then exposed 7 days to extremely low-frequency magnetic fields. Interestingly, the same treatment decreases the lipoperoxidation in the cerebrum. The stressed animals that received concomitant extremely low frequency magnetic fields exposure showed an oxidative status like stressed animals by 21 days. Thus, no changes were observed on the chronic unpredictable mild stress induced-oxidative damage in the rat’s cerebrum by the extremely low-frequency magnetic field exposure together with chronic unpredictable mild stress. The extremely low-frequency electromagnetic field exposure can partially restore the cerebrum antioxidant system of previously stressed animals.

中文翻译：

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极低频磁场对慢性不可预知轻度应激实验模型大鼠大脑氧化平衡的影响

人们越来越关注研究极低频磁场对生命系统的影响。极低频磁场对生物体的作用机制尚未确定。其中一个假设与诱导氧化平衡的变化有关。在这项研究中，我们测量了暴露于极低频磁场的大鼠大脑的慢性不可预测的轻度应激诱导氧化平衡的影响。进行了第一个实验，以确定 14 天的慢性不可预测的轻度压力是否会导致雄性 Wistar 大鼠大脑中的氧化失衡。在大脑和小脑中测量了过氧化氢酶活性、降低的谷胱甘肽浓度和脂质过氧化。在第二个实验中，我们研究了 7 天极低频磁场暴露对有压力和无压力的动物的影响。获得的主要结果是在第 14 天暂停慢性不可预测的轻度应激，然后将其暴露于极低频磁场 7 天的动物大脑中，过氧化氢酶活性显着增加，谷胱甘肽浓度降低。有趣的是，相同的治疗降低了大脑中的脂质过氧化。接受伴随极低频磁场暴露的应激动物在 21 天时表现出与应激动物一样的氧化状态。因此，极低频磁场暴露与慢性不可预知的轻度应激对大鼠大脑的慢性不可预知的轻度应激诱导的氧化损伤没有观察到变化。极低频的电磁场暴露可以部分恢复先前受压动物的大脑抗氧化系统。