Pathological grading of non-invasive urothelial carcinoma has a direct impact upon management. This study evaluates the reproducibility of grading these tumours on glass slides and digital pathology. Forty eight non-invasive urothelial bladder carcinomas were graded by three uropathologists on glass and on a digital platform using the 1973 WHO and 2004 ISUP/WHO systems. Consensus grades for glass and digital grading gave Cohen’s kappa scores of 0.78 (2004) and 0.82 (1973). Of 142 decisions made on the key therapeutic borderline of low grade versus high grade urothelial carcinoma (2004) by the three pathologists, 85% were in agreement. For the 1973 grading system, agreement overall was 90%. Agreement on grading on glass slide and digital screen assessment is similar or in some cases improved, suggesting at least non-inferiority of DP for grading of non-invasive urothelial carcinoma.

中文翻译：

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数字病理学对非浸润性尿路上皮癌分级进行常规诊断的验证

非浸润性尿路上皮癌的病理分级对治疗有直接影响。本研究评估了在载玻片和数字病理学上对这些肿瘤进行分级的可重复性。3 名泌尿病理学家使用 1973 年 WHO 和 2004 年 ISUP/WHO 系统在玻璃和数字平台上对 48 种非侵入性尿路上皮膀胱癌进行了分级。玻璃和数字分级的共识等级给出 Cohen 的 kappa 分数为 0.78 (2004) 和 0.82 (1973)。在三位病理学家就低级别与高级别尿路上皮癌（2004 年）的关键治疗边界做出的 142 项决定中，85% 的决定是一致的。对于 1973 年的分级系统，总体一致性为 90%。载玻片分级和数字屏幕评估的一致性相似或在某些情况下有所改进，