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SARS-CoV-2 sculpts the immune system to induce sustained virus-specific naïve-like and memory B-cell responses
Clinical & Translational Immunology ( IF 4.6 ) Pub Date : 2021-09-05 , DOI: 10.1002/cti2.1339
Leire de Campos-Mata 1 , Sonia Tejedor Vaquero 1 , Roser Tachó-Piñot 1 , Janet Piñero 2 , Emilie K Grasset 3 , Itziar Arrieta Aldea 4 , Natalia Rodrigo Melero 5 , Carlo Carolis 5 , Juan P Horcajada 4 , Andrea Cerutti 1, 3, 6 , Judit Villar-García 4 , Giuliana Magri 1
Affiliation  

SARS-CoV-2 infection induces virus-reactive memory B cells expressing unmutated antibodies, which hints at their emergence from naïve B cells. Yet, the dynamics of virus-specific naïve B cells and their impact on immunity and immunopathology remain unclear.

中文翻译:

SARS-CoV-2 塑造免疫系统以诱导持续的病毒特异性幼稚样和记忆 B 细胞反应

SARS-CoV-2 感染会诱导病毒反应性记忆 B 细胞表达未突变的抗体,这暗示它们是从幼稚 B 细胞中出现的。然而,病毒特异性初始 B 细胞的动态及其对免疫和免疫病理学的影响仍不清楚。
更新日期:2021-09-06
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