Expression of CD49f defines subsets of human regulatory T cells with divergent transcriptional landscape and function that correlate with ulcerative colitis disease activity,Clinical & Translational Immunology

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Expression of CD49f defines subsets of human regulatory T cells with divergent transcriptional landscape and function that correlate with ulcerative colitis disease activity
Clinical & Translational Immunology ( IF 4.6 ) Pub Date : 2021-09-06 , DOI: 10.1002/cti2.1334
Harshi Weerakoon _{1,

2,

3} , Jasmin Straube ₄ , Katie Lineburg ₅ , Leanne Cooper ₄ , Steven Lane _{4,

6} , Corey Smith ₅ , Saleh Alabbas ₇ , Jakob Begun _{6,

7,

8} , John J Miles _{9,

10} , Michelle M Hill _{1,

11} , Ailin Lepletier _{9,

12}

Affiliation

Precision and Systems Biomedicine Laboratory QIMR Berghofer Medical Research Institute Herston QLD Australia.
School of Biomedical Sciences The University of Queensland Brisbane QLD Australia.
Department of Biochemistry Faculty of Medicine and Allied Sciences Rajarata University of Sri Lanka Saliyapura Sri Lanka.
Gordon and Jessie Gilmour Leukaemia Research Laboratory QIMR Berghofer Medical Research Institute Herston QLD Australia.
Translational and Human Immunology Laboratory QIMR Berghofer Medical Research Institute Herston QLD Australia.
School of Medicine University of Queensland Brisbane QLD Australia.
Inflammatory Bowel Diseases Research Group Mater Research Institute University of Queensland Brisbane QLD Australia.
Mater Hospital Brisbane Brisbane QLD Australia.
Human Immunity Laboratory QIMR Berghofer Medical Research Institute Herston QLD Australia.
Centre for Biodiscovery and Molecular Development of Therapeutics James Cook University Cairns QLD Australia.
Centre for Clinical Research Faculty of Medicine The University of Queensland Brisbane QLD Australia.
Laboratory of Vaccines for the Developing World Institute for Glycomics Southport QLD Australia.

Adoptive regulatory T cell (Treg) therapy is being trialled for the treatment of different autoimmune disorders, including inflammatory bowel diseases (IBD). In-depth understanding of the biological variability of Treg in the human blood may be required to improve IBD immune monitoring and treatment strategies.

中文翻译：

CD49f 的表达定义了具有与溃疡性结肠炎疾病活动相关的不同转录景观和功能的人类调节性 T 细胞亚群

过继性调节性 T 细胞 (Treg) 疗法正在试验用于治疗不同的自身免疫性疾病，包括炎症性肠病 (IBD)。可能需要深入了解人体血液中 Treg 的生物学变异性，以改进 IBD 免疫监测和治疗策略。

更新日期：2021-09-06

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