Development of complications in type-1 diabetes patients can be reduced by modifying risk factors. We used a cross-sectional cohort of 1646 patients diagnosed with type 1 diabetes (T1D) to develop a clinical risk score for diabetic peripheral neuropathy (DPN), autonomic neuropathy (AN), retinopathy (DR), and nephropathy (DN). Of these patients, 199 (12.1%) had DPN, 63 (3.8%) had AN, 244 (14.9%) had DR, and 88 (5.4%) had DN. We selected five variables to include in each of the four microvascular complications risk models: age, age of T1D diagnosis, duration of T1D, and average systolic blood pressure and HbA1C over the last three clinic visits. These variables were selected for their strong evidence of association with diabetic complications in the literature and because they are modifiable risk factors. We found the optimism-corrected R2 and Harrell’s C statistic were 0.39 and 0.87 for DPN, 0.24 and 0.86 for AN, 0.49 and 0.91 for DR, and 0.22 and 0.83 for DN respectively.

中文翻译：

---

T1DMicro：1 型糖尿病相关微血管并发症的临床风险计算器

可以通过改变风险因素来减少 1 型糖尿病患者并发症的发生。我们使用由 1646 名诊断为 1 型糖尿病 (T1D) 的患者组成的横断面队列来制定糖尿病周围神经病变 (DPN)、自主神经病变 (AN)、视网膜病变 (DR) 和肾病 (DN) 的临床风险评分。在这些患者中，199 名 (12.1%) 患有 DPN，63 名 (3.8%) 患有 AN，244 名 (14.9%) 患有 DR，88 名 (5.4%) 患有 DN。我们选择了五个变量以包含在四个微血管并发症风险模型中的每一个中：年龄、T1D 诊断年龄、T1D 持续时间以及过去 3 次就诊的平均收缩压和 HbA1C。选择这些变量是因为它们与文献中的糖尿病并发症相关的有力证据，并且因为它们是可改变的风险因素。