Abstract: Extracellular vesicles (EVs), as nanoscale membranous vesicles containing DNAs, RNAs, lipids and proteins, have emerged as promising diagnostic and therapeutic agents for skin diseases. Here, we summarize the basic physiology of the skin and the biological characteristic of EVs. Further, we describe the applications of EVs in the treatment of dermatological conditions such as skin infection, inflammatory skin diseases, skin repair and rejuvenation and skin cancer. In particular, plant-derived EVs and clinical trials are discussed. In addition, challenges and perspectives related to the preclinical and clinical applications of EVs are highlighted.

Keywords: extracellular vesicles, skin diseases, plant, clinical trials


中文翻译：

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细胞外囊泡：皮肤病变的新兴疗法

摘要：细胞外囊泡 (EVs) 作为含有 DNA、RNA、脂质和蛋白质的纳米级膜囊泡，已成为有前途的皮肤病诊断和治疗剂。在这里，我们总结了皮肤的基本生理学和 EV 的生物学特性。此外，我们描述了 EV 在治疗皮肤病方面的应用，如皮肤感染、炎症性皮肤病、皮肤修复和年轻化以及皮肤癌。特别讨论了植物来源的电动汽车和临床试验。此外，还强调了与 EV 的临床前和临床应用相关的挑战和前景。

关键词：细胞外囊泡，皮肤病，植物，临床试验