Background The associations of geographic atrophy (GA) progression with systemic health status and medication use are unclear. Methods We manually delineated GA in 318 eyes in the Age-Related Eye Disease Study. We calculated GA perimeter-adjusted growth rate as the ratio between GA area growth rate and mean GA perimeter between the first and last visit for each eye (mean follow-up=5.3 years). Patients’ history of systemic health and medications was collected through questionnaires administered at study enrolment. We evaluated the associations between GA perimeter-adjusted growth rate and 27 systemic health factors using univariable and multivariable linear mixed-effects regression models. Results In the univariable model, GA perimeter-adjusted growth rate was associated with GA in the fellow eye at any visit (p=0.002), hypertension history (p=0.03), cholesterol-lowering medication use (p<0.001), beta-blocker use (p=0.02), diuretic use (p<0.001) and thyroid hormone use (p=0.03). Among the six factors, GA in the fellow eye at any visit (p=0.008), cholesterol-lowering medication use (p=0.002), and diuretic use (p<0.001) were independently associated with higher GA perimeter-adjusted growth rate in the multivariable model. GA perimeter-adjusted growth rate was 51.1% higher in patients with versus without cholesterol-lowering medication use history and was 37.8% higher in patients with versus without diuretic use history. Conclusions GA growth rate may be associated with the fellow eye status, cholesterol-lowering medication use, and diuretic use. These possible associations do not infer causal relationships, and future prospective studies are required to investigate the relationships further. Data are available upon reasonable request. The data in the age-related eye disease study is available in the database of Genotypes and Phenotypes (dbGaP Study Accession: phs000001.v3.p1). The raw data in our study are available on reasonable request sent to the corresponding author.

中文翻译：

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全身健康和药物使用与年龄相关性黄斑变性地图状萎缩扩大率的关系


背景 地理萎缩（GA）进展与全身健康状况和药物使用的关系尚不清楚。方法 在年龄相关眼病研究中，我们手动描绘了 318 只眼睛的 GA。我们将 GA 周长调整增长率计算为 GA 面积增长率与每只眼睛第一次和最后一次就诊之间的平均 GA 周长之间的比率（平均随访 = 5.3 年）。通过研究登记时进行的调查问卷收集患者的全身健康和药物史。我们使用单变量和多变量线性混合效应回归模型评估了 GA 周长调整后的增长率与 27 个全身健康因素之间的关联。结果 在单变量模型中，GA 周长调整增长率与任何访视时对侧眼的 GA (p=0.002)、高血压病史 (p=0.03)、降胆固醇药物使用 (p<0.001)、β-阻滞剂的使用（p=0.02）、利尿剂的使用（p<0.001）和甲状腺激素的使用（p=0.03）。在这六个因素中，任何访视时对侧眼的 GA (p=0.008)、降胆固醇药物的使用 (p=0.002) 和利尿剂的使用 (p<0.001) 与较高的 GA 周长调整增长率独立相关。多变量模型。有降胆固醇药物使用史的患者与无降胆固醇药物使用史的患者相比，GA 周长调整后的增长率高出 51.1%，有利尿剂使用史的患者比无利尿剂使用史的患者高 37.8%。结论 GA 增长率可能与其他眼部状况、降胆固醇药物的使用和利尿剂的使用有关。这些可能的关联并不能推断出因果关系，需要未来的前瞻性研究来进一步调查这些关系。数据可根据合理要求提供。 年龄相关眼病研究的数据可在基因型和表型数据库中获取（dbGaP 研究登录号：phs000001.v3.p1）。我们研究中的原始数据可根据合理要求发送给通讯作者。