Prior studies with permanent lesion methods have demonstrated a role for the retrosplenial cortex (RSC) in the retrieval of remotely, but not recently, acquired delay fear conditioning. To extend the generalizability of these prior findings, the present experiments used chemogenetics to temporarily inactivate the RSC during either retrieval or encoding of delay auditory fear conditioning. Inactivation of the RSC at the time of test impaired retrieval of a remotely conditioned auditory cue, but not a recently conditioned one. In addition, inactivation of the RSC during encoding had no impact on freezing during later retrieval testing for both a remotely and recently conditioned auditory cue. These findings indicate that the RSC contributes to the retrieval, but not encoding, of remotely acquired auditory fear conditioning, and suggest it has less of a role in both retrieval and encoding of recently acquired auditory fear conditioning.

先前使用永久性损伤方法的研究已经证明了压后皮质 (RSC) 在远程检索（但不是最近）获得性延迟恐惧条件反射中的作用。为了扩展这些先前发现的普遍性，本实验使用化学遗传学在延迟听觉恐惧条件反射的检索或编码期间暂时使 RSC 失活。测试时 RSC 的失活会损害远程调节听觉线索的检索，但不是最近调节的听觉线索。此外，编码期间 RSC 的失活对远程和最近条件听觉线索的后期检索测试期间的冻结没有影响。这些发现表明，RSC 有助于检索，但不是编码，远程获得的听觉恐惧条件反射，