Metal–organic frameworks (MOFs) are materials with a large surface area and antimicrobial properties are advantageous properties for the controlled release of molecules for biomedical applications. However, their synthesis is expensive and harmful to the environment due to the use of organic ligands and solvents. Thus, this work proposes the synthesis of a new MOF by hydrothermal method using water as the solvent, aluminium nitrate as a metallic source, and bis(2-hydroxyethyl) terephthalate (BHET) as organic ligand, obtained via glycolysis of polyethylene terephthalate (PET); and its comparison with MIL53-Al MOF, synthesized from terephthalic acid (BDC) as organic ligand. Both MOFs were characterized by XRD, ATR-FTIR, N₂ physisorption, TGA, SEM and XPS; besides their in vitro biocompatibility was tested by porcine fibroblasts viability. The results indicate that aluminium ions are coordinated to both carbonyl and hydroxyl functional groups of the BDC and BHET organic ligands. The new BHET-Al MOF shows higher thermal stability than MIL53-Al, it also exhibits a macroporous structure in comparison with the microporosity of the MIL53-Al. BHET-Al MOF is not cytotoxic for porcine dermal fibroblasts growing on its surface for up to 48 h of culture, thus, this innovative MOF is a promising material for the controlled release of drugs.

金属有机框架 (MOF) 是具有大表面积的材料，抗菌特性是生物医学应用中分子受控释放的有利特性。然而，由于使用有机配体和溶剂，它们的合成昂贵且对环境有害。因此，这项工作提出以水为溶剂，硝酸铝为金属源，对苯二甲酸双（2-羟乙基）酯（BHET）作为有机配体，通过水热法合成新的 MOF，通过聚对苯二甲酸乙二醇酯（PET）的糖酵解获得); 及其与以对苯二甲酸 (BDC) 作为有机配体合成的 MIL53-Al MOF 的比较。两种 MOF 均通过 XRD、ATR-FTIR、N ₂物理吸附、TGA、SEM 和 XPS 进行表征；除了他们的体外通过猪成纤维细胞的生存能力测试生物相容性。结果表明铝离子与 BDC 和 BHET 有机配体的羰基和羟基官能团配位。新型 BHET-Al MOF 显示出比 MIL53-Al 更高的热稳定性，与 MIL53-Al 的微孔相比，它还表现出大孔结构。BHET-Al MOF 对于在其表面生长长达 48 小时的猪真皮成纤维细胞没有细胞毒性，因此，这种创新的 MOF 是一种很有前途的药物控释材料。