Total synthesis of the pseudoindoxyl class of natural products,Organic & Biomolecular Chemistry

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Total synthesis of the pseudoindoxyl class of natural products
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2021-08-17 , DOI: 10.1039/d1ob01285a
Pawan S Dhote _{1,

2} , Pitambar Patel _{2,

3} , Kumar Vanka _{2,

4} , Chepuri V Ramana _{1,

2}

Affiliation

The pseudoindoxyl sub-structural motif, amongst the large set of the indole class of alkaloids, represents a unique subset of the oxygenated indole class of the alkaloid family. A majority of this class of natural products contains complex bridged/polycyclic scaffolds with interesting biological profiles. They are thus attractive synthetic targets. Starting from 1963, twenty-eight natural products having the pseudoindoxyl scaffold have been isolated, among which the synthesis of 13 natural products has been accomplished. In this review, we highlight the completed as well as the formal total synthesis of the natural products with a spiro-pseudoindoxyl ring, with a focus on their development. The challenges and the future perspective based on the recent developments in the field will also be discussed. We strongly believe that this review will not only update but also attract the attention of researchers in dealing with the synthesis of pseudoindoxyl compounds.

中文翻译：

假吲哚类天然产物的全合成

在大量的吲哚类生物碱中，假吲哚基亚结构基序代表了生物碱家族的氧化吲哚类的独特子集。大多数此类天然产物包含具有有趣生物学特征的复杂桥接/多环支架。因此，它们是有吸引力的合成目标。从1963年开始，已分离出28个具有假吲哚骨架的天然产物，其中已完成13个天然产物的合成。在这篇综述中，我们重点介绍了具有螺-假吲哚环的天然产物的已完成和正式全合成，重点是它们的开发。还将讨论基于该领域最近发展的挑战和未来前景。

更新日期：2021-09-06

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