Purpose

The association between alcohol intake and glioma remains unclear. We evaluated the association between alcohol intake and incidence of glioma in three large, prospective cohort studies with repeated alcohol assessments.

Methods

We harnessed data from three studies with repeat alcohol assessment to compute hazard ratios (HR) and 95% confidence intervals (CI) for glioma by overall alcohol intake and intake from specific beverages using Cox proportional hazards regression, adjusted for age, cohort, body mass index, smoking status, and caloric intake. Analyses were conducted separately for glioma overall and for glioblastoma (GBM).

Results

We confirmed 554 incident glioma cases (362 GBM) among 237,505 participants with 6,216,378 person-years of follow up. Cumulative average alcohol intake was associated with reduced risk of glioma (HR = 0.75, 95%CI:0.56–0.99 comparing > 8–15 to ≤ 0.5 g/d; HR = 0.71, 95%CI:0.53–0.96 comparing > 15 g/d to ≤ 0.5 g/d). When stratified by sex, for the same comparisons, the HRs for men were 0.57 (95%CI:0.36–0.89) and 0.79 (0.53–1.16), and for women 0.90 (95%CI:0.62–1.30) and 0.62, 95%CI:0.39–0.97. Results were consistent when examining cumulative average, baseline, and recent intake, and with a 4 year lag.

Conclusion

These results provide evidence against a positive association between alcohol intake and glioma risk. Alcohol intake was associated with reduced risk of glioma in both men and women.

中文翻译：

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酒精摄入量和神经胶质瘤风险：三项前瞻性队列研究的结果

目的

酒精摄入与神经胶质瘤之间的关联仍不清楚。我们在三项大型前瞻性队列研究中评估了酒精摄入与神经胶质瘤发病率之间的关联，并进行了反复酒精评估。

方法

我们利用来自三项重复酒精评估的研究的数据，使用 Cox 比例风险回归，根据年龄、队列、体重调整后的总体酒精摄入量和特定饮料的摄入量计算神经胶质瘤的风险比 (HR) 和 95% 置信区间 (CI)指数、吸烟状况和热量摄入。对整体胶质瘤和胶质母细胞瘤 (GBM) 分别进行分析。

结果

我们在 237,505 名参与者中确认了 554 例胶质瘤病例 (362 GBM)，随访时间为 6,216,378 人年。累积平均酒精摄入量与胶质瘤风险降低相关（HR = 0.75, 95%CI:0.56-0.99 比较 > 8-15 至 ≤ 0.5 g/d；HR = 0.71, 95%CI:0.53-0.96 比较 > 15 g /d 至 ≤ 0.5 g/d)。按性别分层时，对于相同的比较，男性的 HR 为 0.57 (95%CI:0.36–0.89) 和 0.79 (0.53–1.16)，女性的 HR 为 0.90 (95%CI:0.62–1.30) 和 0.62, 95 %CI：0.39–0.97。在检查累积平均值、基线和最近摄入量时，结果是一致的，并且有 4 年的滞后。

结论

这些结果提供了反对酒精摄入量与神经胶质瘤风险之间存在正相关关系的证据。酒精摄入与男性和女性神经胶质瘤风险降低有关。