Substances that interfere with the body's hormonal balance or their function are called endocrine disrupting chemicals (EDCs). Many EDCs are ubiquitous in the environment and are an unavoidable aspect of daily life, including during early embryogenesis. Developmental exposure to these chemicals is of critical relevance, as EDCs can permanently alter developmental programs, including those that pattern and wire the brain. Of emerging interest is how these chemicals may also affect the immune response, given the cross-talk between the endocrine and immune systems. As brain development is strongly dependent on hormones including thyroid, androgens, and estrogens, and can also be affected by immunomodulation, this complicated interplay may have long-lasting neurodevelopmental consequences. This review focuses on data available from human cohorts, in vivo models, and in vitro assays regarding the impact of EDCs after a gestational and/or lactational exposure, and how they may impact the immune system and/or neurodevelopment.

干扰人体荷尔蒙平衡或其功能的物质称为内分泌干扰物 (EDC)。许多内分泌干扰物在环境中无处不在，是日常生活中不可避免的一个方面，包括在早期胚胎发生过程中。发育接触这些化学物质至关重要，因为内分泌干扰物可以永久改变发育程序，包括那些模式化和连接大脑的程序。考虑到内分泌系统和免疫系统之间的相互作用，新出现的兴趣是这些化学物质如何影响免疫反应。由于大脑发育强烈依赖于包括甲状腺、雄激素和雌激素在内的激素，并且还会受到免疫调节的影响，因此这种复杂的相互作用可能会对神经发育产生长期影响。这篇综述侧重于人类队列中的可用数据，体内模型，以及关于妊娠期和/或哺乳期接触后 EDCs 影响的体外试验，以及它们如何影响免疫系统和/或神经发育。