This study evolves an ultrasensitive label free electrical device, the silicon nanowire field effect transistor (SiNW FET) for cardiac troponin I (cTnI) in acute myocardial infarction (AMI). In this work, SiNW FET is designed, simulated using COMSOL semiconductor module to identify the presence of different concentrations of cTnI present in human blood. The surface of the SiNW is functionalized with the cTnI monoclonal antibody (mAb-cTnI) on attached to detect cTnI antigen. The response of the device is also studied using cTnI at different concentrations with the lowest limit of detection of 0.002 ng/mL. The presented SiNW FET in this study shows considerable response than the earlier developed devices and signify impressive capability for subsequent implementation in point-of-care (PoC) detection.

这项研究开发了一种超灵敏的无标记电子设备，即用于急性心肌梗死 (AMI) 中心肌肌钙蛋白 I (cTnI) 的硅纳米线场效应晶体管 (SiNW FET)。在这项工作中，设计了 SiNW FET，并使用 COMSOL 半导体模块进行了模拟，以识别人体血液中不同浓度的 cTnI 的存在。SiNW 的表面通过连接的 cTnI 单克隆抗体 (mAb-cTnI) 进行功能化，以检测 cTnI 抗原。还使用不同浓度的 cTnI 研究了设备的响应，最低检测限为 0.002 ng/mL。本研究中展示的 SiNW FET 显示出比早期开发的设备有相当大的响应，并表明其在即时 (PoC) 检测中的后续实施能力令人印象深刻。