Heinrich Hoffmann (1809–1894) is the author of Der Struwwelpeter (Shaggy Peter, 1845), a famous collection of moralistic tales for children. He was a psychiatrist who founded the mental asylum in Frankfurt am Mein. In 1859, Hoffmann published a book on “Observations on mental disorders and epilepsy”, following the classification system proposed by Wilhelm Griesinger (1817–1868). Herein, Hoffmann explores, among others, the influence of lunar phases, seasonality, and circadian rhythm on seizure frequency, topics that continue to be object of investigation. In his monograph, Hoffmann refers to some patients with seizure semiology showing a somatotopic distribution and spreading to different body regions. Although devoid of physiopathological or anatomo-clinical interpretation, these observations precede by almost ten years the first description of the march of seizure activity from an initial focus made by John Hughlings Jackson (1835–1911). Consistently with the main topic of his book, Hofmann discusses in detail the association between altered mental states and epileptic seizures, reporting the first case of forced normalization, a phenomenon later described by the Swiss neuropsychiatrist Hans Heinrich Landolt (1917–1971) in 1953.

海因里希·霍夫曼 (1809–1894) 是Der Struwwelpeter的作者（毛茸茸的彼得，1845），著名的儿童道德故事集。他是一位精神病学家，在美因河畔法兰克福创立了精神病院。1859 年，霍夫曼按照威廉·格里辛格 (Wilhelm Griesinger，1817-1868 年) 提出的分类系统出版了一本关于“对精神障碍和癫痫的观察”的书。在此，Hoffmann 探索了月相、季节性和昼夜节律对癫痫发作频率的影响，这些主题仍然是研究的对象。在他的专着中，霍夫曼提到了一些癫痫患者，他们的癫痫症状表现出躯体分布并扩散到不同的身体区域。尽管缺乏病理生理学或解剖学的解释，这些观察比约翰·休林斯·杰克逊 (John Hughlings Jackson) (1835-1911) 最初关注的癫痫发作活动的进程早了将近十年。与其书的主题一致，霍夫曼详细讨论了精神状态改变与癫痫发作之间的关联，报告了第一个强迫正常化的案例，瑞士神经精神病学家汉斯·海因里希·兰多尔特（Hans Heinrich Landolt，1917-1971）在 1953 年描述了这种现象。