Objective

To investigate the shape differences in the putamen of early-onset Parkinson’s patients compared with healthy controls and to assess and to assess sub-regional brain abnormalities.

Methods

This study was conducted using the 3-T MRI scans of 23 early-onset Parkinson’s patients and age and gender matched control subjects. Landmark coordinate data obtained and Procrustes analysis was used to compare mean shapes. The relationships between the centroid sizes of the left and right putamen, and the durations of disease examined using growth curve models.

Results

While there was a significant difference between the right putamen shape of control and patient groups, there was not found a significant difference in terms of left putamen. Sub-regional analyses showed that for the right putamen, the most prominent deformations were localized in the middle-posterior putamen and minimal deformations were seen in the anterior putamen.

Conclusion

Although they were not as pronounced as those in the right putamen, the deformations in the left putamen mimic the deformations in the right putamen which are found mainly in the middle-posterior putamen and at a lesser extend in the anterior putamen.

中文翻译：

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早发性帕金森病壳核形态统计分析

客观的

研究早发性帕金森病患者与健康对照相比壳核的形状差异，并评估和评估次区域脑异常。

方法

这项研究是使用 23 名早发性帕金森病患者以及年龄和性别匹配的对照受试者的 3-T MRI 扫描进行的。获得的地标坐标数据和 Procrustes 分析用于比较平均形状。使用生长曲线模型检查左右壳核质心大小与疾病持续时间之间的关系。

结果

虽然对照组和患者组的右壳核形状存在显着差异，但在左壳核方面没有发现显着差异。亚区域分析表明，对于右壳核，最突出的变形位于中后壳，最小的变形发生在前壳。

结论

尽管它们不像右壳核中的那样明显，但左壳核的变形与右壳核的变形相似，右壳核主要存在于中后壳核中，而在前壳核中的延伸较小。