Dectin-1 is a C-type lectin receptor (CLR) expressed on the surface of various mammalian myeloid cells. Dectin-1 recognizes β-glucans and elicits antifungal proinflammatory immune responses. Recent studies have begun to examine the biology of Dectin-1 in previously less explored settings, such as homeostasis, sterile inflammation, and in the central nervous system. Indeed, in certain contexts, Dectin-1 is now known to promote tolerance, and anti-inflammatory and neuroprotective responses. In this review, we provide an overview of the current understanding of the roles of Dectin-1 in immunology beyond the context of fungal infections, mainly focusing on in vivo neuroimmunology studies, which could reveal new therapeutic approaches to modify innate immune responses in neurologic disorders.

Dectin-1是一种C型凝集素受体(CLR)，表达于多种哺乳动物骨髓细胞表面。Dectin-1 识别 β-葡聚糖并引发抗真菌促炎免疫反应。最近的研究已经开始在以前较少探索的环境中检查 Dectin-1 的生物学特性，例如稳态、无菌炎症和中枢神经系统。事实上，在某些情况下，Dectin-1 现在已知可以促进耐受性、抗炎和神经保护反应。在这篇综述中，我们概述了目前对 Dectin-1 在真菌感染之外的免疫学中的作用的理解，主要关注体内神经免疫学研究，这可能揭示改变神经系统疾病先天免疫反应的新治疗方法。