Transcriptional factors act as mediators in regulating stress response in plants from signal perception to processing the directed gene expression. WRKY, MYB, AP2/ERF, etc. are some of the major families of transcription factors known to mediate stress mechanisms in plants by regulating the production of secondary metabolites. NAC domain-containing proteins are among these large transcription factors families in plants. These proteins play impulsive roles in plant growth, development, and various abiotic as well as biotic stresses. They are involved in regulating the different signaling pathways of plant hormones that direct a plant's immunity against pathogens, thereby affecting their immune responses. However, their role in stress regulation or defence mechanism in plants through the secondary metabolite biosynthesis pathway is studied for very few cases. Emerging concern over the requirement of medicinal plants for the production of biocompatible drugs and antibiotics, the study of these vast, affecting proteins should be focused to improve their qualitative and quantitative production further. In medicinal plants, phytochemicals and secondary metabolites are the major biochemicals that impose antimicrobial and other medicinal properties in these plants. This review compiles the NAC transcription factors reported in selected medicinal plants and their possible roles in different mechanisms. Further, the comprehensive understanding of the molecular mechanism, genetic engineering, and regulation responses of NAC TFs in medicinal plants, can lead to improvement in stress response, immunity, and production of usable secondary metabolites.

转录因子充当调节植物中从信号感知到处理定向基因表达的应激反应的介质。WRKY、MYB、AP2/ERF 等是已知通过调节次生代谢产物的产生来介导植物应激机制的一些主要转录因子家族。含有 NAC 结构域的蛋白质属于植物中的这些大型转录因子家族。这些蛋白质在植物生长、发育以及各种非生物和生物胁迫中发挥着推动作用。它们参与调节植物激素的不同信号通路，指导植物对病原体的免疫，从而影响它们的免疫反应。然而，在极少数情况下研究了它们通过次生代谢物生物合成途径在植物中的应激调节或防御机制中的作用。对药用植物生产生物相容性药物和抗生素的需求的新关注，这些巨大的影响蛋白质的研究应该集中在进一步提高它们的定性和定量生产。在药用植物中，植物化学物质和次生代谢物是在这些植物中施加抗菌和其他药用特性的主要生化物质。本综述汇编了选定药用植物中报道的 NAC 转录因子及其在不同机制中的可能作用。此外，全面了解药用植物中NAC TFs的分子机制、基因工程和调控反应，