A combination of reversible deactivation radical polymerization (RDRP), isocyanate chemistry, and a convenient drying process via spray drying is employed to fabricate powder-form biodegradable liquid-core microcapsules. Two different molecular weight α,ω-poly(ε caprolactone) RDRP macroinitiators were first prepared through esterification to obtain the degradable α-halo ester initiators. Subsequently, poly(benzyl methacrylate-co-isocyanatoethyl methacrylate) (P(BnMA_a-co-IEM_b)) copolymers were synthesized from the RDRP macroinitiators using a copper(0)-mediated polymerization system at ambient temperature. By controlling the macroinitiator to monomer feeding ratio from 1:50 to 1:100, the resultant copolymers had number average molecular weights (M_n) in the range of 7900–17800 g mol⁻¹ with dispersities (Đ) of 1.42-1.52. Afterward, the isocyanate-containing copolymers were employed in the fabrication of particles via interfacial polymerization, followed by a water removal process using spray drying. All polymers and particles were thoroughly characterized using a range of spectroscopic, chromatographic and microscopy analyses.

可逆失活的自由基聚合（RDRP），异氰酸酯化学和方便干燥过程的组合经由喷雾干燥用于制造粉末形式的生物可降解的液芯的微胶囊。首先通过酯化反应制备两种不同分子量的α,ω-聚（ε-己内酯）RDRP大分子引发剂，得到可降解的α-卤代酯引发剂。随后，聚（甲基丙烯酸苄酯-co-异氰酸根合乙基甲基丙烯酸酯）（P（BnMA _a - co -IEM _b)) 共聚物是在环境温度下使用铜 (0) 介导的聚合系统从 RDRP 大分子引发剂合成的。通过控制大分子引发剂与单体投料比例从1:50至1：100，所得到的共聚物具有的数均分子量（中号_Ñ在7900-17800克mol的范围内）^-1与分散度（Đ的1.42-1.52）。然后，含异氰酸酯的共聚物用于通过界面聚合制造颗粒，然后使用喷雾干燥进行脱水过程。使用一系列光谱、色谱和显微镜分析对所有聚合物和颗粒进行了彻底表征。