The synthesis of ROS-responsive polymers has attracted much attentions in recent years. Herein, we report a series of amphiphilic methoxy poly(ethylene glycol)-b-poly(carbonate-selenide)s (mPEG₄₅-b-poly(MSe)_m, m = 12, 24, 36, 48, 60) by introducing selenide groups onto the backbone via one-pot lipase-catalyzed ring-opening polymerization (ROP), the synthesized amphiphilic polymers with enhanced ROS-responsiveness can self-assemble to form nanoparticles. Nuclear Magnetic Resonance (NMR), Gel Permeation Chromatography (GPC) and Fourier Transform Infrared (FTIR) are employed to confirm the structure of the polymers. Besides, the oxidation process of mPEG₄₅-b-poly(MSe)_m nanoparticles is also clarified. Ultraviolet–visible Spectrophotometer (UV–Vis), Dynamic Light Scattering (DLS) and Transmission Electron Microscopy (TEM) are further utilized to demonstrate the turbidity, morphology and size changes under oxidization, proving that the selenide groups endow the mPEG₄₅-b-poly(MSe)_m nanoparticles with enhanced ROS-response properties. Therefore, the above studies highlight the synthesized ROS-responsive polymers and provided a potential material for further applications.

近年来，ROS响应聚合物的合成引起了广泛关注。在此，我们报告了一系列两亲性甲氧基聚（乙二醇）-b-聚（碳酸酯-硒化物）s（mPEG ₄₅ - b -poly(MSe) _m, m = 12, 24, 36, 48, 60）通过引入通过一锅脂肪酶催化的开环聚合（ROP）将硒基团连接到骨架上，合成的具有增强的 ROS 响应性的两亲聚合物可以自组装形成纳米颗粒。采用核磁共振 (NMR)、凝胶渗透色谱 (GPC) 和傅立叶变换红外 (FTIR) 来确认聚合物的结构。此外，mPEG ₄₅ - b的氧化过程-poly(MSe) _m纳米粒子也被澄清。紫外-可见分光光度计 (UV-Vis)、动态光散射 (DLS) 和透射电子显微镜 (TEM) 进一步用于证明氧化下的浊度、形态和尺寸变化，证明硒化物基团赋予了 mPEG ₄₅ - b -具有增强的 ROS 响应特性的聚 (MSe) _m纳米颗粒。因此，上述研究突出了合成的 ROS 响应聚合物，并为进一步应用提供了潜在的材料。