Copper (Cu) and zinc (Zn) imbalances are common in dialysis patients. This study aimed to investigate the relationship between the blood Cu/Zn ratio and anemia in patients undergoing maintenance hemodialysis (MHD) treatment. This cross-sectional study included patients undergoing MHD at our center in September 2019. Clinical and demographic data and blood samples were collected before the hemodialysis sessions, and the blood levels of Zn and Cu were measured by inductively coupled plasma mass spectrometry. Multivariable linear and binary logistic regression analyses were performed to study the relationship between blood Cu/Zn ratio and anemia. A total of 144 MHD patients were enrolled in this study. The patients had a mean age of 64.33 ± 13.39 years, a median dialysis vintage of 33.50 (16.25–57.50) months, with 66 being females (45.8%). The median blood Cu/Zn ratio was 15.55 (interquartile range: 12.47–20.31). Anemia was present in 99 patients (68.8%). Groups with higher hemoglobin levels had decreased blood Cu/Zn ratios (p < 0.05). After adjustments for confounding factors, higher blood Cu/Zn ratios were independently associated with lower hemoglobin levels and anemia in MHD patients based on multivariate linear and multivariate binary logistic regression, respectively, in different models. Our study found that the blood Cu/Zn ratio is independently associated with anemia in MHD patients, but prospective multicenter studies with larger sample sizes are still needed to determine the appropriate cutoff values for blood zinc, blood copper, and blood Cu/Zn levels in this patient population.

铜 (Cu) 和锌 (Zn) 失衡在透析患者中​​很常见。本研究旨在探讨接受维持性血液透析 (MHD) 治疗的患者血液 Cu/Zn 比值与贫血之间的关系。这项横断面研究包括 2019 年 9 月在我们中心接受 MHD 的患者。在血液透析之前收集临床和人口统计数据以及血液样本，并通过电感耦合等离子体质谱法测量血液中的 Zn 和 Cu 水平。进行多变量线性和二元逻辑回归分析以研究血铜/锌比值与贫血之间的关系。本研究共招募了 144 名 MHD 患者。患者的平均年龄为 64.33 ± 13.39 岁，中位透析时间为 33.50 (16.25-57.50) 个月，其中女性 66 人 (45.8%)。中位血铜/锌比率为 15.55（四分位距：12.47-20.31）。99 名患者 (68.8%) 出现贫血。血红蛋白水平较高的组的血铜/锌比值降低（p  < 0.05)。在调整混杂因素后，在不同模型中，分别基于多变量线性和多变量二元逻辑回归，较高的血液 Cu/Zn 比率与 MHD 患者的较低血红蛋白水平和贫血独立相关。我们的研究发现血铜/锌比值与 MHD 患者的贫血独立相关，但仍需要更大样本量的前瞻性多中心研究来确定血锌、血铜和血铜/锌水平的适当临界值。这个患者群体。