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Predictors of aneurysm occlusion following treatment with the WEB device: systematic review and case series
Neurosurgical Review ( IF 2.5 ) Pub Date : 2021-09-04 , DOI: 10.1007/s10143-021-01638-7
Fadi Al Saiegh 1 , Lohit Velagapudi 1 , Omaditya Khanna 1 , Ahmad Sweid 1 , Nikolaos Mouchtouris 1 , Michael P Baldassari 1 , Thana Theofanis 1 , Rizwan Tahir 1 , Victoria Schunemann 1 , Carrie Andrews 1 , Lucas Philipp 1 , Nohra Chalouhi 2 , Stavropoula I Tjoumakaris 1 , David Hasan 3 , M Reid Gooch 1 , Nabeel A Herial 1 , Robert H Rosenwasser 1 , Pascal Jabbour 1
Affiliation  

The Woven EndoBridge (WEB) device is becoming increasingly popular for treatment of wide-neck aneurysms. As experience with this device grows, it is important to identify factors associated with occlusion following WEB treatment to guide decision making and screen patients at high risk for recurrence. The aim of this study was to identify factors associated with adequate aneurysm occlusion following WEB device treatment in the neurosurgical literature and in our case series. A systematic review of the present literature was conducted to identify studies related to the prediction of WEB device occlusion. In addition, a retrospective review of our institutional data for patients treated with the WEB device was performed. Demographics, aneurysm characteristics, procedural variables, and 6-month follow-up angiographic outcomes were recorded. Seven articles totaling 450 patients with 456 aneurysms fit our criteria. Factors in the literature associated with inadequate occlusion included larger size, increased neck width, partial intrasaccular thrombosis, irregular shape, and tobacco use. Our retrospective review identified 43 patients with 45 aneurysms. A total of 91.1% of our patients achieved adequate occlusion at a mean follow-up time of 7.32 months. Increasing degree of contrast stasis after WEB placement on the post-deployment angiogram was significantly associated with adequate occlusion on follow-up angiogram (p = 0.005) and with Raymond-Roy classification (p = 0.048), but not with retreatment (p = 0.617). In our systematic review and case series totaling 450 patients with 456 aneurysms, contrast stasis on post-deployment angiogram was identified as a predictor of adequate aneurysm occlusion, while morphological characteristics such as larger size and wide neck negatively impact occlusion.



中文翻译:

使用 WEB 设备治疗后动脉瘤闭塞的预测因素:系统评价和病例系列

Woven EndoBridge (WEB) 设备在治疗宽颈动脉瘤方面越来越受欢迎。随着使用该设备的经验的增长,识别与 WEB 治疗后闭塞相关的因素以指导决策和筛查复发风险高的患者非常重要。本研究的目的是在神经外科文献和我们的病例系列中确定与 WEB 装置治疗后充分动脉瘤闭塞相关的因素。对现有文献进行了系统回顾,以确定与预测 WEB 设备遮挡相关的研究。此外,我们对使用 WEB 设备治疗的患者的机构数据进行了回顾性审查。记录人口统计学、动脉瘤特征、程序变量和 6 个月随访血管造影结果。共有 450 名患者和 456 个动脉瘤的 7 篇文章符合我们的标准。文献中与闭塞不充分相关的因素包括较大的尺寸、增加的颈部宽度、部分囊内血栓形成、不规则形状和烟草使用。我们的回顾性审查确定了 43 名患者的 45 个动脉瘤。我们共有 91.1% 的患者在平均 7.32 个月的随访时间内实现了充分的闭塞。在部署后血管造影上放置 WEB 后造影剂停滞程度的增加与后续血管造影的充分闭塞显着相关。我们的回顾性审查确定了 43 名患者的 45 个动脉瘤。我们共有 91.1% 的患者在平均 7.32 个月的随访时间内实现了充分的闭塞。在部署后血管造影上放置 WEB 后造影剂停滞程度的增加与后续血管造影的充分闭塞显着相关。我们的回顾性审查确定了 43 名患者的 45 个动脉瘤。我们共有 91.1% 的患者在平均 7.32 个月的随访时间内实现了充分的闭塞。在部署后血管造影上放置 WEB 后造影剂停滞程度的增加与后续血管造影的充分闭塞显着相关。p  = 0.005) 和 Raymond-Roy 分类 ( p  = 0.048),但不包括再处理 ( p  = 0.617)。在我们的系统回顾和病例系列中,总共有 450 名患者和 456 个动脉瘤,部署后血管造影上的对比剂停滞被确定为充分动脉瘤闭塞的预测因素,而较大尺寸和宽颈等形态特征对闭塞有负面影响。

更新日期:2021-09-04
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