Disruption of rack1 suppresses SHH-type medulloblastoma formation in mice,CNS Neuroscience & Therapeutics

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Disruption of rack1 suppresses SHH-type medulloblastoma formation in mice
CNS Neuroscience & Therapeutics ( IF 4.8 ) Pub Date : 2021-09-04 , DOI: 10.1111/cns.13728
Fengjiao Liu ₁ , Jingyuan Shao ₁ , Haihong Yang ₂ , Guochao Yang ₃ , Qian Zhu ₁ , Yan Wu ₁ , Lingling Zhu ₁ , Haitao Wu _{1,

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Affiliation

Medulloblastoma (MB) is a malignant pediatric brain tumor that arises in the cerebellar granular neurons. Sonic Hedgehog subtype of MB (SHH-MB) is one of the major subtypes of MB in the clinic. However, the molecular mechanisms underlying MB tumorigenesis are still not fully understood.

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